{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T13:00:35Z","timestamp":1777899635859,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2009,7,23]],"date-time":"2009-07-23T00:00:00Z","timestamp":1248307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2009,7,23]],"date-time":"2009-07-23T00:00:00Z","timestamp":1248307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Appl Imm"],"abstract":"<jats:p>Human peripheral blood lymphocytes from healthy individuals were examined to detect the presence of membrane-bound Ig and surface receptors for fixed IgG and fixed C3. These three features are thought to be characteristic of B lymphocytes and were measured by the mixed antiglobulin rosetting reaction, the antibody (Fc) rosetting reaction and complement (C3) rosetting reactions, respectively. As a reaction believed to be characteristic of T lymphocytes, the capacity to rosette with non-sensitized SRBC was also evaluated. Mean percentages of the total number of lymphocytes from 20 healthy donors \u00b1 1 SD were: sheep red blood cell rosetting reaction 55.7 \u00b1 9.6; mixed antiglobulin rosetting reaction 34.3 \u00b1 9.6; Fc rosetting reaction 26.3 \u00b1 9.9, and C3 rosetting reaction 14.7 \u00b1 5.2. Having established a range of normal values, eleven patients with chronic lymphatic leukaemia (CLL) were examined. For all the reactions believed characteristic of B lymphocytes the mean percentage of lymphocytes rosetting was increased; mixed antiglobulin rosettes 85.8; Fc rosettes 60.4, and C3 rosettes 56.4. There was consequent reduction in the mean percentage of lymphocytes rosetting with SRBC, i.e. 11.8%. This confirms that, in the cases studied, CLL is a disorder of B lymphocytes. In normal persons and in CLL patients it was found that Fc receptors, C3 receptors and Ig determinants appeared to express themselves independently on B lymphocytes.<\/jats:p>","DOI":"10.1159\/000231155","type":"journal-article","created":{"date-parts":[[2009,7,24]],"date-time":"2009-07-24T07:20:14Z","timestamp":1248420014000},"page":"525-538","source":"Crossref","is-referenced-by-count":31,"title":["B and T Lymphocyte Subpopulations in Human Peripheral Blood"],"prefix":"10.1159","author":[{"given":"D.G.","family":"Haegert","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Hallberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.R.A.","family":"Coombs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,7,23]]},"container-title":["International Archives of Allergy and Applied Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/231155","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000231155","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T10:09:47Z","timestamp":1777630187000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000231155"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,7,23]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000231155","archive":["Portico"],"relation":{},"ISSN":["0020-5915","2571-6662"],"issn-type":[{"value":"0020-5915","type":"print"},{"value":"2571-6662","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,7,23]]}}}