{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T13:01:10Z","timestamp":1777899670539,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2009,7,23]],"date-time":"2009-07-23T00:00:00Z","timestamp":1248307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2009,7,23]],"date-time":"2009-07-23T00:00:00Z","timestamp":1248307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Appl Imm"],"abstract":"<jats:p>The immunogenicity of purified hyaluronic acid (HA) from human umbilical cord and rooster comb, and of some modified HA preparations, was studied in rabbits. HA preparations contained 0.28\u20130.57% of protein or peptides (Folin\u2019s method). Rabbits received four intramuscular injections at 4-weekly intervals of the following potential immunogens, emulsified in complete Freund\u2019s adjuvant: (1) human umbilical cord HA (HUC-HA), 500 \u03bcg\/dose; (2) HUC-HA, precipitated with cetylpyridinium chloride (CPC), 500 \u03bcg\/dose; (3) HUC-HA-ovalbumin conjugate, precipitated with CPC, 500 \u03bcg\/dose, and (4) rooster comb HA at dose levels of 5, 50 and 500 \u03bcg. Rabbit sera were tested before, during, and after immunization for PCA reactive antibodies against HA in guinea pigs. 11 of 25 pre-immunization sera showed low titres of HA-cross-reactive antibodies. No formation of PCA reactive antibodies against any of the four HA preparations was observed during or after immunization.<\/jats:p>","DOI":"10.1159\/000231214","type":"journal-article","created":{"date-parts":[[2009,7,28]],"date-time":"2009-07-28T02:24:43Z","timestamp":1248747883000},"page":"211-217","source":"Crossref","is-referenced-by-count":43,"title":["Non-Immunogenicity of Purified Hyaluronic Acid Preparations Tested by Passive Cutaneous Anaphylaxis"],"prefix":"10.1159","author":[{"given":"Wolfgang","family":"Richter","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,7,23]]},"container-title":["International Archives of Allergy and Applied Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/231214","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000231214","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T10:10:40Z","timestamp":1777630240000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000231214"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,7,23]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000231214","archive":["Portico"],"relation":{},"ISSN":["0020-5915","2571-6662"],"issn-type":[{"value":"0020-5915","type":"print"},{"value":"2571-6662","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,7,23]]}}}