{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T13:01:40Z","timestamp":1777899700027,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2009,7,23]],"date-time":"2009-07-23T00:00:00Z","timestamp":1248307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2009,7,23]],"date-time":"2009-07-23T00:00:00Z","timestamp":1248307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Appl Imm"],"abstract":"<jats:p>On the basis of their physicochemical and antigenic properties, and by analogy with guinea pig immunoglobulins, two antibody classes in the serum of the marsupial Setonix brachyurus have been classified as IgG&lt;sub&gt;1&lt;\/sub&gt; and IgG&lt;sub&gt;2&lt;\/sub&gt; isotypes. The analogy between these marsupial immunoglobulins and those of eutherian (placental) species was extended by an investigation of their biological activities. The electrophoretically slow antibody (IgG&lt;sub&gt;2&lt;\/sub&gt;) fixed hemolytic complement, precipitated soluble antigen and predominated early in the response mounted when quokkas were immunized with antigen emulsified in Freund\u2019s complete adjuvant (FCA). The more anodic antibody (IgG&lt;sub&gt;1&lt;\/sub&gt;) in this marsupial did not fix complement, was inefficient in precipitating antigen and was the predominant antibody synthesized by quokkas immunized with antigen adsorbed to alumina gel. The IgG&lt;sub&gt;1&lt;\/sub&gt; isotype in this marsupial appears to possess both passive hemagglutinating (HA) and homocytotropic antibody (HCA) activities. However, the HCA and IgG&lt;sub&gt;1&lt;\/sub&gt; HA activities did not develop in parallel during the course of the immune response, thus suggesting that only a functional subpopulation of the IgG&lt;sub&gt;1&lt;\/sub&gt; antibodies possess homocytotropic activity.<\/jats:p>","DOI":"10.1159\/000231310","type":"journal-article","created":{"date-parts":[[2009,7,28]],"date-time":"2009-07-28T02:24:43Z","timestamp":1248747883000},"page":"236-247","source":"Crossref","is-referenced-by-count":0,"title":["Immunoglobulin Classes Carrying Homocytotropic and Passive Hemagglutinating Antibody Activities in the Marsupial Setonix brachyurus (the Quokka)"],"prefix":"10.1159","author":[{"given":"N.R.","family":"Lynch","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.J.","family":"Turner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.G.","family":"Bell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,7,23]]},"container-title":["International Archives of Allergy and Applied Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/231310","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000231310","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T10:11:58Z","timestamp":1777630318000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000231310"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,7,23]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000231310","archive":["Portico"],"relation":{},"ISSN":["0020-5915","2571-6662"],"issn-type":[{"value":"0020-5915","type":"print"},{"value":"2571-6662","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,7,23]]}}}