{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:45:37Z","timestamp":1745469937523,"version":"3.40.4"},"reference-count":11,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gynecol Obstet Invest"],"published-print":{"date-parts":[[2009]]},"abstract":"<i>Objective:<\/i> The aim of the study was to determine the association between three single nucleotide polymorphism (SNP) variants (rs35368790, rs35069869 and rs684846) of the MCF2 cell line-derived transforming sequence-like 2 <i>(MCF2L2)<\/i> gene and polycystic ovary syndrome (PCOS) in PCOS family trios. <i>Methods:<\/i> Genotyping was done by TaqMan assay that incorporates minor groove-binding probe technology for allelic discrimination. One hundred and fifty-two unrelated PCOS probands and their biological parents were recruited. All subjects were of Han Chinese origin and from Shandong Province. <i>Results:<\/i> The transmission disequilibrium test (TDT) for allelic association demonstrated that a weak association was detected in SNP rs35368790 with p = 0.008. However, we found no significant transmission distortion of the other two SNPs (rs35069869, \u03c7<sup>2<\/sup> = 3.645, p = 0.056; rs684846, \u03c7<sup>2<\/sup> = 1.429, p = 0.232, respectively). <i>Conclusions:<\/i> These results suggest that the genetic polymorphisms within <i>MCF2L2<\/i> are likely to confer an increased susceptibility to PCOS in the Chinese population. Our present data may provide a basis for further studies of the role of the <i>MCF2L2<\/i> gene in the etiology of PCOS.<\/jats:p>","DOI":"10.1159\/000231520","type":"journal-article","created":{"date-parts":[[2009,7,31]],"date-time":"2009-07-31T11:27:44Z","timestamp":1249039664000},"page":"171-173","source":"Crossref","is-referenced-by-count":5,"title":["Family-Based Association Study of the <i>MCF2L2<\/i> Gene and Polycystic Ovary Syndrome"],"prefix":"10.1159","volume":"68","author":[{"given":"Qingmei","family":"Zheng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuhua","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zongli","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinghua","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laicheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fuzhong","family":"Xue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harvest F.","family":"Gu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zi-Jiang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,7,31]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2003-032046"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.85.7.2434"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMra041536"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1210%2Fer.2004-0004"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2FS1472-6483%2810%2961114-5"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.81.11.4174"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007%2Fs10038-008-0254-6"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1093%2Fbioinformatics%2Fbth457"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.coph.2007.12.006"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.yjmcc.2008.01.011"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1530%2FEJE-07-0576"}],"container-title":["Gynecologic and Obstetric Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/231520","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/231520","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T22:11:30Z","timestamp":1745446290000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000231520"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009]]},"references-count":11,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2009,10,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000231520","archive":["Portico"],"relation":{},"ISSN":["0378-7346","1423-002X"],"issn-type":[{"type":"print","value":"0378-7346"},{"type":"electronic","value":"1423-002X"}],"subject":[],"published":{"date-parts":[[2009]]}}}