{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T13:04:52Z","timestamp":1777899892743,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2009,7,24]],"date-time":"2009-07-24T00:00:00Z","timestamp":1248393600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2009,7,24]],"date-time":"2009-07-24T00:00:00Z","timestamp":1248393600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Appl Imm"],"abstract":"<jats:p>Human myeloma proteins of IgG&lt;sub&gt;4&lt;\/sub&gt; subclass in contrast to myeloma proteins IgG&lt;sub&gt;1&lt;\/sub&gt;, IgG&lt;sub&gt;2&lt;\/sub&gt; and IgG&lt;sub&gt;3&lt;\/sub&gt;, were capable of blocking PCA reactions in monkeys mediated by human reaginic antibodies of IgE class. In addition to IgE, IgG&lt;sub&gt;4&lt;\/sub&gt; myeloma protein was also capable of sensitizing leukocytes from normal individuals and gave histamine release (HR) upon challenge with anti-human IgG&lt;sub&gt;4&lt;\/sub&gt;. Leukocytes from 11 allergic individuals and from 9 normal subjects sensitized with the serum of allergic patients, were capable of releasing histamine with anti-human IgG&lt;sub&gt;4&lt;\/sub&gt;, anti-human IgE, and the specific allergen. No response was obtained with anti-human IgG&lt;sub&gt;1&lt;\/sub&gt; and IgG&lt;sub&gt;3&lt;\/sub&gt; sera. Leukocytes from the normal individuals released histamine from 3 to 20% with anti-human IgG&lt;sub&gt;4&lt;\/sub&gt; and from 6 to 30% with anti-human IgE. Moreover, normal leukocytes sensitized with IgG&lt;sub&gt;4&lt;\/sub&gt; myeloma protein or a serum of an allergic patient heated at 56\u00b0C for 2 h, released a significant amount of histamine on challenge with anti-human IgG&lt;sub&gt;4&lt;\/sub&gt; whereas no response was obtained with anti-human IgE. The biological role of human IgG&lt;sub&gt;4&lt;\/sub&gt; in immediate hypersensitivity reactions is discussed in relation to human IgE.<\/jats:p>","DOI":"10.1159\/000231734","type":"journal-article","created":{"date-parts":[[2009,7,28]],"date-time":"2009-07-28T02:24:43Z","timestamp":1248747883000},"page":"78-87","source":"Crossref","is-referenced-by-count":61,"title":["Inhibition of Reagin-Mediated PCA Reactions in Monkeys and Histamine Release from Human Leukocytes by Human IgG\n                    <sub>4<\/sub>\n                    Subclass"],"prefix":"10.1159","author":[{"given":"H.M.","family":"Vijay","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Perelmutter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,7,24]]},"container-title":["International Archives of Allergy and Applied Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/231734","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000231734","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T10:17:32Z","timestamp":1777630652000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000231734"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,7,24]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000231734","archive":["Portico"],"relation":{},"ISSN":["0020-5915","2571-6662"],"issn-type":[{"value":"0020-5915","type":"print"},{"value":"2571-6662","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,7,24]]}}}