{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T13:06:22Z","timestamp":1777899982407,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2009,7,24]],"date-time":"2009-07-24T00:00:00Z","timestamp":1248393600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2009,7,24]],"date-time":"2009-07-24T00:00:00Z","timestamp":1248393600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Appl Imm"],"abstract":"<jats:p>Reagins in murine strains A\/HeJ RF\/J C3H\/HeJ and B6D2FJ were induced by immunization, in the presence of Al(OH)&lt;sub&gt;3&lt;\/sub&gt;, with the retentate (R) obtained by dialysis from the aqueous extract of Kentucky blue grass pollen (KBG-Aq. ext.). Administration of doses of R ranging from 50\u2013200 \u03bcg resulted in IgE antibody responses which were sustained for periods of the order of 6 months. The possibility of suppressing the anti-R IgE antibody response in sensitized A\/HeJ mice was tested by the administration into these animals for a period of 14 weeks, biweekly injections of a skin-active, immunogenic fraction (DI) isolated from the dialysate of KBG-Aq. ext. This treatment effectively suppressed the secondary IgE antibody response to R and markedly increased levels of hemagglutinating antibodies. On the basis of the fact that DI comprised only 1.5% of the parent fraction KBG-Aq. ext. and since it was capable of modulating the immune response to R as described, it is suggested that DI may prove to be a useful agent for the immunotherapy of allergies to KBG pollen.<\/jats:p>","DOI":"10.1159\/000231933","type":"journal-article","created":{"date-parts":[[2009,7,28]],"date-time":"2009-07-28T02:24:43Z","timestamp":1248747883000},"page":"247-254","source":"Crossref","is-referenced-by-count":5,"title":["Suppression of the IgE Antibody Response in Mice to Kentucky Blue Grass Pollen Allergens"],"prefix":"10.1159","author":[{"given":"A.K.M.","family":"Ekramoddoullah","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.T.","family":"Kisil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.H.","family":"Sehon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,7,24]]},"container-title":["International Archives of Allergy and Applied Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/231933","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000231933","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T10:19:51Z","timestamp":1777630791000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000231933"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,7,24]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000231933","archive":["Portico"],"relation":{},"ISSN":["0020-5915","2571-6662"],"issn-type":[{"value":"0020-5915","type":"print"},{"value":"2571-6662","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,7,24]]}}}