{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T13:10:10Z","timestamp":1777900210972,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2009,7,29]],"date-time":"2009-07-29T00:00:00Z","timestamp":1248825600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2009,7,29]],"date-time":"2009-07-29T00:00:00Z","timestamp":1248825600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Appl Imm"],"abstract":"<jats:p>Spectral evidence is presented that 0.01\u20130.03 mM solutions of the antiasthmatic drug doxantrazole contain the neutral or ionized form, depending on the solvent and, at least in 1 case, on concentration. In 1,4-dioxane, where only the neutral form exists, and in water, where the drug is ionized, no reaction between doxantrazole and calcium ion can be demonstrated spectroscopically. However, in 2-propanol at 0.01 mM and in 7:3 (v\/v) 1,4-dioxane-water the doxantrazole anion can be shown to react with calcium. In more concentrated 2-propanol solutions most of the drug is in the neutral form, and no reaction with calcium is evident. It is suggested that in a biological system doxantrazole can react directly with calcium but such a reaction will depend on the state of the drug and the nature of its environment.<\/jats:p>","DOI":"10.1159\/000232417","type":"journal-article","created":{"date-parts":[[2009,7,29]],"date-time":"2009-07-29T09:44:38Z","timestamp":1248860678000},"page":"75-80","source":"Crossref","is-referenced-by-count":1,"title":["Interaction of Doxantrazole with Calcium Ions in Solvents of Intermediate Polarity"],"prefix":"10.1159","author":[{"given":"J.C.","family":"Spitzer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,7,29]]},"container-title":["International Archives of Allergy and Applied Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/232417","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000232417","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T10:25:57Z","timestamp":1777631157000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000232417"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,7,29]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000232417","archive":["Portico"],"relation":{},"ISSN":["0020-5915","2571-6662"],"issn-type":[{"value":"0020-5915","type":"print"},{"value":"2571-6662","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,7,29]]}}}