{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T22:17:54Z","timestamp":1759961874288,"version":"3.40.4"},"reference-count":20,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Res Paediatr"],"published-print":{"date-parts":[[2009]]},"abstract":"<i>Aim:<\/i> To investigate the relationship of forearm length (FL) or height to bone parameters of the forearm of a normal pediatric population in comparison to individuals with osteogenesis imperfecta (OI). <i>Methods:<\/i> Data on FL, height and peripheral quantitative computed tomography measurements of the forearm were collected from participants of the DONALD study (140 males and 156 females; age 5\u201319 years) and from 73 patients with OI (53 males; mean age \u00b1 SD: 11.7 \u00b1 3.3 years). Bone mineral content (BMC) was transformed into standard deviation score (SDS) according to height or FL. <i>Results:<\/i> Height and Tanner stages significantly predicted FL in males (R<sup>2<\/sup><sub>adjusted<\/sub> = 0.960) and females (R<sup>2<\/sup><sub>adjusted<\/sub> = 0.934). Height was a stronger predictor of FL than Tanner stages. Compared to controls, patients with OI were characterized by lower BMC-SDS<sub>FL<\/sub> and lower BMC-SDS<sub>height<\/sub> (\u20130.37 \u00b1 1.77 vs. 0.00 \u00b1 0.97, p = 0.002, and \u20130.15 \u00b1 5.0 vs. \u20130.02 \u00b1 1.01, p = 0.011, respectively). BMC-SDS<sub>FL<\/sub> was not significantly lower than BMC-SDS<sub>height<\/sub> in controls, and also not lower in patients with OI (p = 0.865 and p = 0.809). The height\/FL ratio was significantly decreased in patients with OI (mean \u00b1 SD: 6.34 \u00b1 0.38 vs. 6.45 \u00b1 0.21, p = 0.001) compared with controls. <i>Conclusion:<\/i> Because of disproportional growth, BMC may be overestimated in OI patients.<\/jats:p>","DOI":"10.1159\/000232493","type":"journal-article","created":{"date-parts":[[2009,9,4]],"date-time":"2009-09-04T13:04:16Z","timestamp":1252069456000},"page":"172-177","source":"Crossref","is-referenced-by-count":3,"title":["Forearm Length \u2013 A New Tool to Standardize Bone Parameters of the Forearm Measured with Peripheral Quantitative Computed Tomography in Individuals with Disproportional Growth of Forearm Length and Body Height"],"prefix":"10.1159","volume":"72","author":[{"given":"Oliver","family":"Fricke","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oliver","family":"Semler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralf","family":"Beccard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christof","family":"Land","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roland","family":"Ehrlich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Remer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eckhard","family":"Schoenau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,9,1]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ghir.2006.10.004"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007%2Fs007740070001"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097%2F00005768-200005000-00006"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007%2Fs002239900384"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.86.2.613"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2FS8756-3282%2800%2900429-4"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1530%2Feje.0.151S087"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002%2Fajpa.1330350319"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2FS8756-3282%2895%2900162-X"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.85.3.1095"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1203%2F00006450-200109000-00003"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2FS8756-3282%2800%2900405-1"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00223-001-0048-8"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1017%2FS0012162204000787"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2004-1603"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016%2FS8756-3282%2802%2900802-5"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1007%2Fs001980170074"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016%2FS8756-3282%2899%2900104-0"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1007%2FBF01774016"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1177%2F0148607182006003226"}],"container-title":["Hormone Research in Paediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/232493","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/232493","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T22:20:59Z","timestamp":1745446859000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000232493"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009]]},"references-count":20,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2009,9,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000232493","archive":["Portico"],"relation":{},"ISSN":["1663-2818","1663-2826"],"issn-type":[{"type":"print","value":"1663-2818"},{"type":"electronic","value":"1663-2826"}],"subject":[],"published":{"date-parts":[[2009]]}}}