{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T12:10:02Z","timestamp":1785499802510,"version":"3.56.0"},"reference-count":47,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dev Neurosci"],"published-print":{"date-parts":[[2009]]},"abstract":"<jats:p>Neonatal stroke leads to mortality and severe morbidity, but there currently is no effective treatment. Erythropoietin (EPO) promotes cytoprotection and neurogenesis in the short term following brain injury; however, long-term cognitive outcomes and optimal dosing regimens have not been clarified. We performed middle cerebral artery occlusion in postnatal day 10 rats, which were treated with either a single dose of EPO (5 U\/g, i.p.) immediately upon reperfusion, or 3 doses of EPO (1 U\/g, i.p. each) at 0 h, 24 h, and 7 days after injury. At 3 months after injury, rats treated with 3 doses of EPO did not differ from shams in the Morris water maze, and generally performed better than either rats treated with a single dose or vehicle-treated injured rats. These multiple-dose-treated rats also had increases in hemispheric volume and its subregions. These results suggest that additional, later doses of EPO may be required for cell repair, proliferation, and long-term incorporation into neural networks after neonatal brain injury.<\/jats:p>","DOI":"10.1159\/000232558","type":"journal-article","created":{"date-parts":[[2009,8,12]],"date-time":"2009-08-12T13:53:17Z","timestamp":1250085197000},"page":"403-411","source":"Crossref","is-referenced-by-count":108,"title":["Erythropoietin Sustains Cognitive Function and Brain Volume after Neonatal Stroke"],"prefix":"10.1159","volume":"31","author":[{"given":"Fernando F.","family":"Gonzalez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regina","family":"Abel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. Robert","family":"Almli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dezhi","family":"Mu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Wendland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donna M.","family":"Ferriero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2009,8,11]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1097%2F00008480-200112000-00002"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002%2Fana.20557"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1084%2Fjem.20021067"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2FS0006-8993%2802%2903239-0"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2F0149-7634%2895%2900026-7"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1161%2F01.STR.0000132196.49028.a4"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1089%2F152581602321080529"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1097%2F00004647-199906000-00007"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.expneurol.2005.06.001"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1203%2F00006450-199801000-00007"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1006%2Fbbrc.1998.9748"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2FS0387-7604%2803%2900039-1"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1203%2F01.PDR.0000159571.50758.39"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.95.8.4635"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.97.19.10526"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1159%2F000068926"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1097%2F00001756-200309150-00020"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1097%2F01.WCB.0000110049.43905.AC"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.brainres.2004.06.057"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.bbr.2003.11.002"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1203%2F01.PDR.0000155760.88664.06"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1203%2F01.PDR.0000163616.89767.69"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.nbd.2003.08.020"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1159%2F000105473"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1038%2F35088074"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1002%2Fjnr.10166"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.nbd.2006.08.007"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1471-4159.2006.03697.x"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.bbrc.2005.10.218"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1159%2F000088637"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1523%2FJNEUROSCI.5380-05.2006"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1161%2F01.RES.0000224117.59417.f3"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1038%2F35044558"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.nlm.2004.12.001"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.nlm.2005.09.003"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1460-9568.2006.05269.x"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.bbr.2007.09.024"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.bbr.2003.10.017"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.neuroscience.2005.05.041"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.nlm.2006.07.003"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.0953-816X.2004.03248.x"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.brainres.2008.04.010"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.neuroscience.2007.04.054"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.neuroscience.2008.04.023"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291098-1063%281997%297%3A4%3C403%3A%3AAID-HIPO6%3E3.0.CO%3B2-J"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1006%2Fexnr.2000.7492"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.1203%2Fpdr.0b013e3180332cec"}],"container-title":["Developmental Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/232558","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/232558","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T22:21:49Z","timestamp":1745446909000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000232558"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009]]},"references-count":47,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2009,9,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000232558","archive":["Portico"],"relation":{},"ISSN":["0378-5866","1421-9859"],"issn-type":[{"value":"0378-5866","type":"print"},{"value":"1421-9859","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009]]}}}