{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:46:02Z","timestamp":1745469962092,"version":"3.40.4"},"reference-count":26,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dev Neurosci"],"published-print":{"date-parts":[[2009]]},"abstract":"<jats:p>Hypoxic-ischemic brain injury is often delayed and involves both apoptotic and immunoregulatory mechanisms. In this study, we used a neonatal model of hypoxia-ischemia to examine the effect of the mixed lineage kinase (MLK) inhibitor CEP-1347 on brain damage, apoptosis and inflammation. The tissue volume loss was reduced by 28% (p = 0.019) in CEP-1347-treated versus vehicle-treated rats and CEP-1347 significantly attenuated microgliosis at 7 days (p = 0.038). CEP-1347 decreased TUNEL-positive staining as well as cleaved caspase 3 immunoreactivity. CEP-1347 did not affect the expression of pro-inflammatory cytokines IL-1\u03b2, IL-6 and MCP-1, nor did it affect the expression of OX-42 (CR3) and OX-18 (MHC I) 24 h after the insult. In conclusion, the MLK inhibitor CEP-1347 has protective effects in a neonatal rat model of hypoxia-ischemia, which is mainly related to reduced apoptosis.<\/jats:p>","DOI":"10.1159\/000232560","type":"journal-article","created":{"date-parts":[[2009,8,12]],"date-time":"2009-08-12T13:53:17Z","timestamp":1250085197000},"page":"420-426","source":"Crossref","is-referenced-by-count":6,"title":["Role of Mixed Lineage Kinase Inhibition in Neonatal Hypoxia-Ischemia"],"prefix":"10.1159","volume":"31","author":[{"given":"Ylva","family":"Carlsson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna-Lena","family":"Leverin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maj","family":"Hedtj\u00e4rn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carina","family":"Mallard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrik","family":"Hagberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,8,11]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2F0165-0270%2890%2990131-X"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.freeradbiomed.2005.08.040"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1074%2Fjbc.274.20.14046"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1471-4159.2003.02198.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1203%2F00006450-199904010-00008"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1203%2F00006450-199806000-00005"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1172%2FJCI2169"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2FS0169-328X%2897%2900085-5"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097%2F00004647-199802000-00014"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1097%2F01.wco.0000162851.44897.8f"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ddmec.2006.11.003"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1471-4159.2004.02547.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1471-4159.2005.03014.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2F0165-3806%2894%2900177-2"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1471-4159.2005.03590.x"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1212%2F01.wnl.0000277648.63931.c0"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1002%2Fana.410090206"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016%2FS0079-6468%2808%2970081-X"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016%2FS0197-0186%2896%2900072-1"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.bcp.2006.06.031"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1146%2Fannurev.pharmtox.44.101802.121840"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1471-4159.2003.01838.x"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ceb.2007.02.001"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016%2F0003-2697%2880%2990024-X"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1136%2Fadc.64.7_Spec_No.953"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1471-4159.2005.03639.x"}],"container-title":["Developmental Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/232560","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/232560","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T22:21:50Z","timestamp":1745446910000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000232560"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009]]},"references-count":26,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2009,9,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000232560","archive":["Portico"],"relation":{},"ISSN":["0378-5866","1421-9859"],"issn-type":[{"type":"print","value":"0378-5866"},{"type":"electronic","value":"1421-9859"}],"subject":[],"published":{"date-parts":[[2009]]}}}