{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,22]],"date-time":"2026-03-22T09:15:41Z","timestamp":1774170941189,"version":"3.50.1"},"reference-count":38,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dev Neurosci"],"published-print":{"date-parts":[[2009]]},"abstract":"<jats:p>Birth asphyxia is associated with disturbed development of the neonatal brain. In this study, we determined if low-dose melatonin (0.1 mg\/kg\/day), administered to the mother over 7 days at the end of pregnancy, could protect against the effects of birth asphyxia in a precocial species \u2013 the spiny mouse &lt;i&gt;(Acomys cahirinus).&lt;\/i&gt; At 37 days of gestation (term is 38\u201339 days), pups were subjected to birth asphyxia (7.5 min uterine ischemia) and compared to Cesarean section-delivered controls. At 24 h of age, birth asphyxia had increased markers of CNS inflammation (microglia, macrophage infiltration) and apoptosis (activated caspase-3, fractin) in cortical gray matter, which were reduced to control levels by prior maternal melatonin treatment. Melatonin may be an effective prophylactic agent for use in late pregnancy to protect against hypoxic-ischemic brain injury at birth.<\/jats:p>","DOI":"10.1159\/000232562","type":"journal-article","created":{"date-parts":[[2009,8,14]],"date-time":"2009-08-14T09:52:54Z","timestamp":1250243574000},"page":"437-451","source":"Crossref","is-referenced-by-count":47,"title":["Neuroprotective Properties of Melatonin in a Model of Birth Asphyxia in the Spiny Mouse &lt;i&gt;(Acomys cahirinus)&lt;\/i&gt;"],"prefix":"10.1159","volume":"31","author":[{"given":"Lisa 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