{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T01:40:23Z","timestamp":1768009223163,"version":"3.49.0"},"reference-count":53,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dev Neurosci"],"published-print":{"date-parts":[[2009]]},"abstract":"<jats:p>In order to approach the physiopathological mechanism underlying the selective susceptibility of the immature brain to hypoxia-ischemia (HI), we have compared the lesions experimentally induced in postnatal day 7 rats using a model of neonatal stroke with those occurring in human fetal and neonatal brains. We first observed that gray and white matter lesions demonstrated a similar organization (core with cell loss and\/or cavity and penumbra) and evolutionary pattern between experimental and human HI lesions. We then observed that, in the intermediate white matter, GFAP- and vimentin-positive astrocytes exhibited clasmatodendrosis and represent a major cell population involved in cell death in human brains (56.3 and 67.9%, respectively). In rat brains, GFAP- and TUNEL-positive astrocytes were also highly vulnerable, increasing between 6 (31%) and 72 (58%) hours after ischemia. Together, these results indicate that astroglial dysfunction may play a critical role in determining the progress and outcome of acute hypoxic-ischemic injury particularly in the developing brain.<\/jats:p>","DOI":"10.1159\/000232564","type":"journal-article","created":{"date-parts":[[2009,8,12]],"date-time":"2009-08-12T13:53:17Z","timestamp":1250085197000},"page":"459-470","source":"Crossref","is-referenced-by-count":29,"title":["Astrocytic Demise in the Developing Rat and Human Brain after Hypoxic-Ischemic Damage"],"prefix":"10.1159","volume":"31","author":[{"given":"Antoinette","family":"Gelot","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Villapol","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thierry","family":"Billette de Villemeur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylvain","family":"Renolleau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christiane","family":"Charriaut-Marlangue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,8,11]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2FS0165-0173%2899%2900009-0"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1203%2F00006450-200106000-00003"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1750-3639.1992.tb00694.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMsb035364"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1159%2F000069040"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007%2FBF00315011"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2F0165-3806%2894%2900194-5"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002%2Fjnr.490170212"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007%2Fs004010050686"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002%2F1098-1136%28200102%2933%3A2%3C169%3A%3AAID-GLIA1016%3E3.0.CO%3B2-B"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1159%2F000046144"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1159%2F000085987"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.expneurol.2006.01.037"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ijdevneu.2007.08.014"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1203%2F01.PDR.0000059751.00465.F6"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1159%2F000046140"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016%2FS0378-3782%2898%2900037-1"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016%2FS0387-7604%2801%2900243-1"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1023%2FA%3A1026453623753"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1159%2F000047087"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1097%2F01.WCB.0000100061.36077.5F"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.cdd.4401545"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1471-4159.2006.04269.x"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.neuroscience.2007.06.060"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1203%2F00006450-199711000-00022"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1203%2F00006450-200107000-00020"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1007%2Fs10024001-0205-0"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2990.1997.tb01300.x"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1002%2Fglia.1048"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1002%2Fana.410420310"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1016%2FS0169-328X%2899%2900063-7"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1097%2F00004647-200203000-00006"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2990.2003.00467.x"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1002%2Fglia.20167"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1159%2F000072267"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1159%2F000082143"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1002%2Fana.10310"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1055%2Fs-2008-1052453"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1016%2F0887-8994%2895%2900192-1"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1002%2Fmrdd.20106"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1016%2F0014-5793%2876%2980523-6"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1016%2F0736-5748%2889%2990056-7"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1097%2F00004647-200007000-00003"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1016%2F0165-3806%2896%2900043-0"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jocn.2005.10.018"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1016%2FS0006-8993%2896%2901054-2"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.1159%2F000080151"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291098-1136%2820000201%2929%3A3%3C212%3A%3AAID-GLIA3%3E3.0.CO%3B2-6"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.1016%2FS0304-3940%2802%2900146-5"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1440-1754.2005.00585.x"},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.1053%2Fj.semperi.2004.10.007"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.1080%2F08035320310020968"},{"key":"ref53","doi-asserted-by":"publisher","DOI":"10.1097%2F01.jnen.0000263875.22306.3c"}],"container-title":["Developmental Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/232564","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/232564","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T22:21:51Z","timestamp":1745446911000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000232564"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009]]},"references-count":53,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2009,9,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000232564","archive":["Portico"],"relation":{},"ISSN":["0378-5866","1421-9859"],"issn-type":[{"value":"0378-5866","type":"print"},{"value":"1421-9859","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009]]}}}