{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T17:36:33Z","timestamp":1791999393579,"version":"4.4.0"},"reference-count":46,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2009,8,6]],"date-time":"2009-08-06T00:00:00Z","timestamp":1249516800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,8,6]],"date-time":"2009-08-06T00:00:00Z","timestamp":1249516800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Immunol"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Interleukin (IL)-17A is a highly inflammatory cytokine with a robust effect on stromal cells in many tissues. Although IL-17A is known to be associated with inflammatory lung disorders by triggering an accumulation of neutrophils, the effect of IL-17A on the upper airway is still uncertain. The expression of IL-17A and its role were investigated in the nasal polyps of chronic rhinosinusitis associated with asthma. &lt;i&gt;Methods:&lt;\/i&gt; IL-17A was detected by immunohistochemistry and quantitative real-time RT-PCR. The cellular source of IL-17A was examined by double staining with EG2, CD4 and neutrophil elastase. The tissue remodeling of the nasal polyps was evaluated by assessing the epithelial damage and basement membrane thickness. &lt;i&gt;Results:&lt;\/i&gt; Both the immunoreactivity and mRNA of IL-17A were significantly detected in the nasal polyps in comparison with control normal sinus mucosa. The localization of IL-17A expression predominantly coincided with eosinophils and CD4-positive lymphocytes. Furthermore, the number of IL-17A-positive cells correlated with tissue eosinophils, but not with neutrophils. The degree of epithelial damage and basement membrane thickness was dependent on the number of infiltrated IL-17A-positive cells. &lt;i&gt;Conclusion:&lt;\/i&gt; The present study suggests, for the first time, that IL-17A plays an important role in the eosinophil accumulation in the nasal polyps and the remodeling of the nasal polyps of chronic rhinosinusitis associated with asthma.<\/jats:p>","DOI":"10.1159\/000232566","type":"journal-article","created":{"date-parts":[[2009,8,7]],"date-time":"2009-08-07T13:46:18Z","timestamp":1249652778000},"page":"8-16","source":"Crossref","is-referenced-by-count":81,"title":["Role of Interleukin-17A in the Eosinophil Accumulation and Mucosal Remodeling in Chronic Rhinosinusitis with Nasal Polyps Associated with Asthma"],"prefix":"10.1159","volume":"151","author":[{"given":"T.","family":"Saitoh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Kusunoki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Kawano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Kojima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Miyahara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Onoda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Yokoi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Ikeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2009,8,6]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2FS0194-5998%2803%2901397-4"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2FS0091-6749%2897%2970041-1"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaci.2004.09.029"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1398-9995.2006.01132.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1398-9995.2006.01225.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1159%2F000236875"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2FS0091-6749%2896%2970100-8"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1620%2Ftjem.182.115"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.2174%2F1568010023344832"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2F0091-6749%2893%2990035-E"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.2500%2F105065897780914992"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1159%2F000088430"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1067%2Fmai.2000.109269"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007%2Fs11882-006-0027-2"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2F0091-6749%2892%2990180-A"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.2500%2F105065800781329573"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1097%2F01.MLG.0000165380.64445.EE"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1136%2Fthx.17.1.69"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2889%2990067-6"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaci.2003.08.009"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1378%2Fchest.119.5.1329"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1136%2Fthorax.57.7.643"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1067%2Fmai.2001.117929"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2249.2001.01602.x"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1053%2Frmed.2003.1507"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1186%2F1465-9921-7-135"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016%2FS1053-2498%2802%2901234-2"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaci.2004.06.023"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaci.2008.02.018"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1097%2F00005537-200310000-00027"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1398-9995.2005.00830.x"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.2500%2F105065896782103117"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1164%2Frccm.200602-189OC"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1016%2FS0091-6749%2895%2970298-9"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaci.2008.02.018"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1038%2Fni1254"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1038%2Fni1261"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1600-065X.2008.00628.x"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.2332%2Fallergolint.R-07-160"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1159%2F000049511"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1152%2Fajplung.00306.2006"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1165%2Frcmb.4832"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1084%2Fjem.20061401"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1164%2Frccm.200801-086OC"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.1146%2Fannurev.immunol.021908.132710"},{"key":"ref46","do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