{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T07:53:09Z","timestamp":1782978789193,"version":"3.54.5"},"reference-count":26,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiology"],"published-print":{"date-parts":[[2009]]},"abstract":"<i>Objectives:<\/i> Although epilepsy may be associated with an increased risk for sudden cardiac death, its effects on Q-T intervals has not been established. <i>Methods:<\/i> To determine whether changes in Q-T interval duration (QT<sub>max c<\/sub>, QT<sub>min c<\/sub>) and dispersion (QT<sub>D c<\/sub>) occur in epileptic patients, we retrospectively studied 40 consecutive patients (age: 36.1 \u00b1 22.2 years) who have had a seizure disorder for 14.0 \u00b1 12.2 years and were seen in the Epilepsy Monitoring Unit, and 60 age-matched non-epileptic controls (age: 38.0 \u00b1 15.6 years). Q-T intervals were calculated from a single 12-lead ECG. <i>Results:<\/i> QT<sub>max c<\/sub> (425 \u00b1 30 vs. 410 \u00b1 36 ms, p = 0.040) and QT<sub>D c<\/sub> (63.1 \u00b1 22.4 vs. 31.0 \u00b1 17.2 ms, p = 0.000) were higher, and QT<sub>min c<\/sub> (362 \u00b1 36 vs. 379 \u00b1 33 ms, p = 0.040) was lower in epilepsy patients. QT<sub>max c<\/sub> was significantly correlated with disease duration (r = \u20130.35, p = 0.028) before, but not after age correction (r = \u20130.31, p = 0.053). Neither age nor reported recent seizure frequency was correlated with any repolarization index. <i>Conclusions:<\/i> QT<sub>max c<\/sub> and QT<sub>D c<\/sub> are higher in epilepsy patients as compared to control subjects. While Q-T interval appears to be related to disease duration, particularly over the early history of disease, it is unrelated to patient age or recent reported seizure frequency.<\/jats:p>","DOI":"10.1159\/000233236","type":"journal-article","created":{"date-parts":[[2009,8,12]],"date-time":"2009-08-12T13:53:17Z","timestamp":1250085197000},"page":"255-260","source":"Crossref","is-referenced-by-count":47,"title":["Cardiac Repolarization Indices in Epilepsy Patients"],"prefix":"10.1159","volume":"114","author":[{"given":"Gregory","family":"Neufeld","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason M.","family":"Lazar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geetha","family":"Chari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haroon","family":"Kamran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edesiri","family":"Akajagbor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis","family":"Salciccioli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Kassotis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Stewart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2009,8,12]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1053%2Feuhj.1998.1445"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2FS0167-5273%2898%2900348-9"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1054%2Fjelc.2001.28822"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1001%2Farchinte.164.9.943"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ijcard.2007.03.114"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ijcard.2008.04.003"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1159%2F000008105"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1159%2F000089594"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097%2F00001756-200402090-00029"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1097%2F00008506-199907000-00001"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2FS0735-6757%2898%2990224-8"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1001%2Farchneur.57.12.1685"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1053%2Fseiz.2000.0388"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1528-1157.1985.tb05722.x"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1093%2Fbrain%2F124.12.2361"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1080%2F08035250310003550"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2898%2905114-9"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.yebeh.2006.06.001"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016%2FS0920-1211%2898%2900120-X"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016%2F0006-8993%2891%2990412-O"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1002%2Fana.1006"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1528-1167.2008.01545.x"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1136%2Fhrt.2006.087957"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMra000650"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1080%2F07853890600990375"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1093%2Foxfordjournals.eurheartj.a014868"}],"container-title":["Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/233236","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/233236","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T22:28:54Z","timestamp":1745447334000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000233236"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009]]},"references-count":26,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2009,10,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000233236","archive":["Portico"],"relation":{},"ISSN":["0008-6312","1421-9751"],"issn-type":[{"value":"0008-6312","type":"print"},{"value":"1421-9751","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009]]}}}