{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T13:17:04Z","timestamp":1777900624631,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2009,8,4]],"date-time":"2009-08-04T00:00:00Z","timestamp":1249344000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2009,8,4]],"date-time":"2009-08-04T00:00:00Z","timestamp":1249344000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Appl Imm"],"abstract":"<jats:p>The IgE-mediated hypersensitivity to Ascaris antigen in reactor rhesus primates was used to assess the pharmacologic profile of U-60,257, a pyrrole analog of prostacyclin. Whether the compound was given by aerosol or intravenously, it effectively inhibited the bronchopulmonary effects of antigen challenge. Dose responses by the aerosol route showed a dose-dependent inhibition of resistance (R&lt;sub&gt;L&lt;\/sub&gt;) and compliance (C&lt;sub&gt;dyn&lt;\/sub&gt;) changes (100% \u00b1 0 to 10.2% \u00b1 14.5 for RL and 79.9% \u00b1 20 to 0% for C&lt;sub&gt;dyn&lt;\/sub&gt; after 15 breaths of 1.0\u20130.01 % solutions delivered into the lungs; n = 16). When administered at 1.0% by aerosol the duration of the inhibitory effect was 6 h (n = 3). Dose-dependent inhibition in both R&lt;sub&gt;L&lt;\/sub&gt; (93.3% \u00b1 5.6 to 69.4% \u00b1 34.8) and C&lt;sub&gt;dyn&lt;\/sub&gt; (51.4 \u00b1 40.4 to 47.0% \u00b1 28.5) was also seen when the compound was given intravenously (5.0\u20130.01 mg\/kg; n = 16). U-60,257 is a selective inhibitor of leukotriene synthesis in in vitro systems. Therefore, the finding of synergism in the inhibition of response of primates to Ascaris between this compound and the H&lt;sub&gt;1&lt;\/sub&gt; histamine blocker diphenhydramine suggests that the leukotrienes may play an etiologic role in this response.<\/jats:p>","DOI":"10.1159\/000233317","type":"journal-article","created":{"date-parts":[[2009,8,5]],"date-time":"2009-08-05T05:41:56Z","timestamp":1249450916000},"page":"169-173","source":"Crossref","is-referenced-by-count":28,"title":["The Activity of a New, Novel Inhibitor of Leukotriene Synthesis in Rhesus Monkey Ascaris Reactors"],"prefix":"10.1159","author":[{"given":"Herbert G.","family":"Johnson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martha L.","family":"McNee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael K.","family":"Bach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Herman W.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,8,4]]},"container-title":["International Archives of Allergy and Applied Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/233317","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000233317","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T10:36:33Z","timestamp":1777631793000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000233317"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,8,4]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000233317","archive":["Portico"],"relation":{},"ISSN":["0020-5915","2571-6662"],"issn-type":[{"value":"0020-5915","type":"print"},{"value":"2571-6662","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,8,4]]}}}