{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T13:19:13Z","timestamp":1777900753561,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2009,8,4]],"date-time":"2009-08-04T00:00:00Z","timestamp":1249344000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2009,8,4]],"date-time":"2009-08-04T00:00:00Z","timestamp":1249344000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Appl Imm"],"abstract":"<jats:p>Gut mucosal, salivary and serum antibody responses to a new oral cholera vaccine, consisting of B subunit and whole cell vaccine (WCV), were studied in Swedish volunteers. A single immunization with a 0.5mg dose of B subunit together with WCV (5 \u00d7 1010 killed cholera vibrios) induced a local intestinal immunoglobulin A (IgA) antitoxin response in 4\/6 (67%) vaccine recipients as evident from specific antibody titre rises in intestinal lavage fluid. A second administration of vaccine did not further enhance the intestinal immune response beyond the peak level induced by the initial immunization. Different doses of B subunit (2.5 and 0.5 mg) given together with 5 \u00d7 1010 killed vibrios (WCV) induced antitoxin antibody responses in serum in about the same frequency, 10\/13 (77%) responders versus 13\/14 (93%), as well as in saliva, 7\/13 (54%) versus 9\/14 (64%), and a single immunization was almost as efficient as two vaccine administrations. Single or repeated oral vaccination only irregularly resulted in modest antibacterial titre rises in serum (9\/27 = 33%) or saliva (12\/27 = 44%), but stimulated a significant mucosal antibacterial response in intestine of 5\/6 (83%) examined volunteers.<\/jats:p>","DOI":"10.1159\/000233587","type":"journal-article","created":{"date-parts":[[2009,8,5]],"date-time":"2009-08-05T05:41:56Z","timestamp":1249450916000},"page":"38-43","source":"Crossref","is-referenced-by-count":32,"title":["Gut Mucosal, Salivary and Serum Antitoxic and Antibacterial Antibody Responses in Swedes after Oral Immunization with B Subunit-Whole Cell Cholera Vaccine"],"prefix":"10.1159","author":[{"given":"M.","family":"Jertborn","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.-M.","family":"Svennerholm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Holmgren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,8,4]]},"container-title":["International Archives of Allergy and Applied Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/233587","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000233587","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T10:40:37Z","timestamp":1777632037000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000233587"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,8,4]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000233587","archive":["Portico"],"relation":{},"ISSN":["0020-5915","2571-6662"],"issn-type":[{"value":"0020-5915","type":"print"},{"value":"2571-6662","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,8,4]]}}}