{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T13:21:47Z","timestamp":1777900907761,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2009,8,4]],"date-time":"2009-08-04T00:00:00Z","timestamp":1249344000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2009,8,4]],"date-time":"2009-08-04T00:00:00Z","timestamp":1249344000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Appl Imm"],"abstract":"<jats:p>The purpose of this study was to investigate the pulmonary effects of hyperventilation in anesthetized, mechanically ventilated guinea pigs. Airway resistance (Raw), dynamic lung compliance (C&lt;sub&gt;Dyn&lt;\/sub&gt;), blood pressure (BP), heart rate (HR), arterial blood gases (PaO&lt;sub&gt;2&lt;\/sub&gt;, PaCO&lt;sub&gt;2&lt;\/sub&gt;), pH and arterial plasma HCO&lt;sub&gt;3&lt;\/sub&gt;\u2013\u2013 were measured before and after a 10-min period of hyperventilation produced by increasing the respiratory rate from 60 to 120 breaths\/min while maintaining tidal volume at 4 ml. There was a significant increase in R&lt;sub&gt;aw&lt;\/sub&gt; and decrease in C&lt;sub&gt;Dyn&lt;\/sub&gt; lasting up to 20 min after hyperventilation was stopped with no change in BP and HR. PaO&lt;sub&gt;2&lt;\/sub&gt; was reduced from 109 \u00b1 3 mm Hg before to 53 \u00b1 7 mm Hg at 5 min after hyperventilation. The R&lt;sub&gt;aw&lt;\/sub&gt; and C&lt;sub&gt;Dyn&lt;\/sub&gt; changes were prevented and reversed with the bronchodilators salbutamol and aminophylline indicating that reversible bronchospasms are induced in guinea pigs following a period of hyperventilation. Additional studies demonstrated that the pulmonary mechanical responses to hyperventilation were not changed by vagotomy, ventilation with high CO&lt;sub&gt;2&lt;\/sub&gt; or by pretreatment with chlorpheniramine, methysergide, atropine, indomethacin, FPL 55712 or calcium-influx blockers. These results indicate that neither vagal reflexes, airway hypocapnia, receptors of histamine, serotonin, acetylcholine nor the products of arachidonic acid metabolism were involved in hyperventilation-induced bronchospasm in guinea pigs.<\/jats:p>","DOI":"10.1159\/000233883","type":"journal-article","created":{"date-parts":[[2009,8,5]],"date-time":"2009-08-05T05:41:56Z","timestamp":1249450916000},"page":"190-196","source":"Crossref","is-referenced-by-count":18,"title":["Hyperventilation-Induced Bronchoconstriction in Guinea Pigs"],"prefix":"10.1159","author":[{"given":"Richard W.","family":"Chapman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gisela","family":"Danko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,8,4]]},"container-title":["International Archives of Allergy and Applied Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/233883","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000233883","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T10:45:14Z","timestamp":1777632314000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000233883"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,8,4]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000233883","archive":["Portico"],"relation":{},"ISSN":["0020-5915","2571-6662"],"issn-type":[{"value":"0020-5915","type":"print"},{"value":"2571-6662","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,8,4]]}}}