{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T13:26:57Z","timestamp":1777901217852,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2009,8,5]],"date-time":"2009-08-05T00:00:00Z","timestamp":1249430400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2009,8,5]],"date-time":"2009-08-05T00:00:00Z","timestamp":1249430400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Appl Imm"],"abstract":"<jats:p>Nickel sulfate (NiSO&lt;sub&gt;4&lt;\/sub&gt;) and nickel chloride (NiCl&lt;sub&gt;2&lt;\/sub&gt;) were evaluated as sensitizers in the Guinea Pig Maximization Test (GPMT). The highest concentrations of NiSO&lt;sub&gt;4&lt;\/sub&gt; or NiCl&lt;sub&gt;2&lt;\/sub&gt; used as an intradermal challenge (0.25 and 0.5%) yielded responses that were significantly different (p &lt; 0.05) between exposed and control guinea pigs at 24 h, and the highest concentration (0.5%) yielded significant differences (p &lt; 0.05) at 48 h. The responses at the 0.125% NiSO&lt;sub&gt;4&lt;\/sub&gt; challenge site were significantly greater (p &lt; 0.05) than for controls at both 24 and 48 h. Using the lymphocyte transformation test (LTT), the stimulation indices for the NiSO&lt;sub&gt;4&lt;\/sub&gt;- and NiCl&lt;sub&gt;2&lt;\/sub&gt;-exposed guinea pigs were nearly identical; however, the difference between exposed and control groups was greater for NiSO&lt;sub&gt;4&lt;\/sub&gt; than for NiCl&lt;sub&gt;2&lt;\/sub&gt;. The results of both intradermal skin challenge and lymphocyte transformation indicated that NiSO&lt;sub&gt;4&lt;\/sub&gt; may be preferable to NiCl&lt;sub&gt;2&lt;\/sub&gt; in the GPMT. Because the skin test yielded statistically significant results while LTT did not, the skin test may be of more value when using these sensitizers in the GPMT.<\/jats:p>","DOI":"10.1159\/000234527","type":"journal-article","created":{"date-parts":[[2009,8,7]],"date-time":"2009-08-07T09:46:18Z","timestamp":1249638378000},"page":"332-336","source":"Crossref","is-referenced-by-count":1,"title":["Comparison of NiSO\n                    <sub>4<\/sub>\n                    and NiCl\n                    <sub>2<\/sub>\n                    as Sensitizers in the Guinea Pig"],"prefix":"10.1159","author":[{"given":"Richard","family":"Dorn","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald D.","family":"Warner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wael","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,8,5]]},"container-title":["International Archives of Allergy and Applied Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/234527","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000234527","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T10:55:16Z","timestamp":1777632916000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000234527"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,8,5]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000234527","archive":["Portico"],"relation":{},"ISSN":["0020-5915","2571-6662"],"issn-type":[{"value":"0020-5915","type":"print"},{"value":"2571-6662","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,8,5]]}}}