{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T13:37:21Z","timestamp":1777901841907,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2009,8,7]],"date-time":"2009-08-07T00:00:00Z","timestamp":1249603200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2009,8,7]],"date-time":"2009-08-07T00:00:00Z","timestamp":1249603200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Appl Imm"],"abstract":"<jats:p>The in vitro release of endogenous and exogenous PgF&lt;sub&gt;2&lt;\/sub&gt;\u03b1 from plasma and serum proteins by aspirin and other analgesic drugs has been studied by RIA and equilibrium-dialysis techniques, respectively. Before aspirin addition, the mean plasma level of PgF&lt;sub&gt;2&lt;\/sub&gt;\u03b1 mesured by RIA was significantly lower in aspirin-sensitive asthma (ASA) patients (11.3 \u00b1 6.5 pg\/ml; n = 8) than in aspirin-tolerant asthma (ATA) patients (25.0 \u00b1 11.4 pg\/ml; n = 21). After aspirin addition (50 \u03bcg\/ml) the mean PgF&lt;sub&gt;2&lt;\/sub&gt;\u03b1 level detected in plasma by RIA was higher in ASA patients (97.6 \u00b1 5.5 pg\/ml) than in ATA patients (66.9 \u00b1 4.5). The binding of [3H]PgF&lt;sub&gt;2&lt;\/sub&gt;\u03b1 to serum protein was significantly inhibited by NSAIDs but not by paracetamol (0.2\u20131.0 mM). These results implicate PgF&lt;sub&gt;2&lt;\/sub&gt;\u03b1 and the protein-binding property of analgesic drugs in the pathogenesis of aspirin-sensitive asthma.<\/jats:p>","DOI":"10.1159\/000235465","type":"journal-article","created":{"date-parts":[[2009,8,7]],"date-time":"2009-08-07T09:46:18Z","timestamp":1249638378000},"page":"303-308","source":"Crossref","is-referenced-by-count":3,"title":["Aspirin-Sensitive Asthma: Significance of the Cyclooxygenase-Inhibiting and Protein-Binding Properties of Analgesic Drugs"],"prefix":"10.1159","author":[{"given":"W.R.","family":"Williams","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Pawlowicz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.H.","family":"Davies","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,8,7]]},"container-title":["International Archives of Allergy and Applied Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/235465","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000235465","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T11:10:38Z","timestamp":1777633838000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000235465"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,8,7]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000235465","archive":["Portico"],"relation":{},"ISSN":["0020-5915","2571-6662"],"issn-type":[{"value":"0020-5915","type":"print"},{"value":"2571-6662","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,8,7]]}}}