{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T13:36:49Z","timestamp":1777901809905,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2009,9,2]],"date-time":"2009-09-02T00:00:00Z","timestamp":1251849600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2009,9,2]],"date-time":"2009-09-02T00:00:00Z","timestamp":1251849600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Appl Imm"],"abstract":"<jats:p>Male Dunkin Hartley guinea pigs, actively sensitized to ovalbumin (OA) and pretreated with mepyramine (1 mg\/kg i.p.), were challenged with OA as an aerosol. Histological analysis of the lung for eosinophils (EOs) showed significant accumulations in the submucosa of the airways (8 h: 1,477.3 \u00b1 43 EOs\/mm2 airway, n = 3, p &lt; 0.01), after antigen challenge compared to saline control (478.6 \u00b1 104 EOs\/mm2 airway, n = 4). Pretreatment with both mepyramine and cimetidine (10 mg\/kg i.p.) did not affect this response. Aerosolization of OA to unsensitized guinea pigs resulted in no significant accumulation of EOs (360.2 \u00b1 49 EOs\/mm2 airway, n = 4) when compared with the saline-challenged sensitized control group. Pretreatment with the leukotriene (LT)D&lt;sub&gt;4&lt;\/sub&gt; receptor antagonist MK-571 (1 mg\/kg p.o.) significantly inhibited the OA-induced EO migration (95 \u00b1 5% inhibition, n = 5, p &lt; 0.01) compared to vehicle in the presence of mepyramine and cimetidine, while indomethacin (3 mg\/kg p.o., n = 4) had no effect. Aerosolization of synthetic LTC&lt;sub&gt;4&lt;\/sub&gt; (0.3\u201330 \u03bcg\/ml) resulted in a dose-dependent migration of EOs into the submucosal layer over 8 h, reaching significance at the 10-\u03bcg\/ml dose, with comparable results obtained with LTD&lt;sub&gt;4&lt;\/sub&gt;. Pretreatment of animals with MK-571 (1 mg\/kg p.o.) before LTC&lt;sub&gt;4&lt;\/sub&gt; and LTD&lt;sub&gt;4&lt;\/sub&gt; aerosol results in inhibition of the response in both cases, suggesting that this effect may be mediated through the LTD&lt;sub&gt;4&lt;\/sub&gt; receptor. We conclude that peptide LTs produce eosinophilia in the airways of the guinea pig.<\/jats:p>","DOI":"10.1159\/000235508","type":"journal-article","created":{"date-parts":[[2009,9,4]],"date-time":"2009-09-04T09:04:16Z","timestamp":1252055056000},"page":"279-284","source":"Crossref","is-referenced-by-count":55,"title":["Peptide Leukotriene Involvement in Pulmonary Eosinophil Migration upon Antigen Challenge in the Actively Sensitized Guinea Pig"],"prefix":"10.1159","author":[{"given":"Aidan","family":"Foster","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chi Chung","family":"Chan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,9,2]]},"container-title":["International Archives of Allergy and Applied Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/235508","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000235508","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T11:11:24Z","timestamp":1777633884000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000235508"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,9,2]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000235508","archive":["Portico"],"relation":{},"ISSN":["0020-5915","2571-6662"],"issn-type":[{"value":"0020-5915","type":"print"},{"value":"2571-6662","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,9,2]]}}}