{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T15:39:15Z","timestamp":1774712355001,"version":"3.50.1"},"reference-count":31,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respiration"],"published-print":{"date-parts":[[2009]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Mediastinal lymph node staging (N-staging) is essential to optimize the treatment in non-small cell lung cancer (NSCLC). Transesophageal endoscopic ultrasonography-guided fine needle aspiration (EUS-FNA) has recently been introduced as a complementary method. However, in most reports, EUS-FNA has been performed in patients who have demonstrated enlarged lymph nodes (LNs) on CT findings. The yield of EUS\/EUS-FNA in patients without enlarged mediastinal LNs by CT has so far only been evaluated in a few reports. &lt;i&gt;Aims:&lt;\/i&gt; Our aim was to compare the diagnostic accuracy of CT and EUS with or without EUS-FNA (EUS\/EUS-FNA) prospectively, for N-stage in all patients with potentially resectable NSCLC, including patients with and without mediastinal LN enlargement based on CT findings. &lt;i&gt;Methods:&lt;\/i&gt; Eighty consecutive patients with potentially resectable NSCLC based on CT findings were enrolled in this prospective comparative study, and underwent EUS\/EUS-FNA. &lt;i&gt;Results:&lt;\/i&gt; Pathological N-stage was established in 78 patients, while in another 2 cases, malignant pleural effusion was proven by EUS-FNA, and we avoided further N-staging. In the 78 patients, the prevalence of malignant mediastinal LNs was 21%. The accuracy of EUS\/EUS-FNA (91%) was significantly higher than that of CT (71%). The negative predictive value of EUS\/EUS-FNA was 90%. In addition, EUS-FNA identified 2 patients as N3 disease in 56 patients without mediastinal LN involvement on CT. &lt;i&gt;Conclusions:&lt;\/i&gt; EUS\/EUS-FNA gave more accurate N-staging in patients with possibly resectable NSCLC than CT, and is thus considered to be useful to determine the optimal treatment strategy.<\/jats:p>","DOI":"10.1159\/000235544","type":"journal-article","created":{"date-parts":[[2009,8,12]],"date-time":"2009-08-12T13:50:19Z","timestamp":1250085019000},"page":"423-431","source":"Crossref","is-referenced-by-count":15,"title":["Mediastinal Lymph Node Staging in Potentially Resectable Non-Small Cell Lung Cancer: A Prospective Comparison of CT and EUS\/EUS-FNA"],"prefix":"10.1159","volume":"78","author":[{"given":"Ichiro","family":"Yasuda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuo","family":"Kato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumihiro","family":"Asano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenichi","family":"Okubo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salem","family":"Omar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuo","family":"Kako","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeo","family":"Yasuda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimiyasu","family":"Sano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nib","family":"Soehendra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisataka","family":"Moriwaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,8,11]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1378%2Fchest.07-1360"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1378%2Fchest.07-1362"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ejcts.2007.01.075"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1378%2Fchest.117.3.773"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1378%2Fchest.123.1_suppl.137S"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1378%2Fchest.123.2.442"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1055%2Fs-2003-40216"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2FS0169-5002%2803%2900229-0"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.giec.2004.07.013"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1378%2Fchest.06-1437"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2F0003-4975%2895%2900052-6"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1200%2FJCO.2005.01.1965"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2FS0003-4975%2801%2903205-2"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.lungcan.2005.04.005"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1001%2Fjama.294.8.931"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.athoracsur.2003.10.009"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1164%2Frccm.200405-581OC"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.lungcan.2006.06.015"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.athoracsur.2004.06.089"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1378%2Fchest.111.6.1710"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1378%2Fchest.111.6.1718"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.rmed.2004.06.011"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016%2FS0016-5107%2897%2970176-7"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1159%2F000097496"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1159%2F000112793"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ejcts.2006.10.026"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1067%2Fmge.2001.117764"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1159%2F000072011"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1378%2Fchest.130.3.710"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1055%2Fs-2005-870276"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1001%2Fjama.299.5.540"}],"container-title":["Respiration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/235544","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/235544","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T22:07:26Z","timestamp":1745446046000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000235544"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009]]},"references-count":31,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2009,10,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000235544","archive":["Portico"],"relation":{},"ISSN":["0025-7931","1423-0356"],"issn-type":[{"value":"0025-7931","type":"print"},{"value":"1423-0356","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009]]}}}