{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:45:29Z","timestamp":1745469929352,"version":"3.40.4"},"reference-count":24,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiology"],"published-print":{"date-parts":[[2009]]},"abstract":"<i>Objectives:<\/i> Controversy exists regarding utility of cardiac troponin I (cTnI) in predicting significant coronary artery disease (CAD) in hemodialysis (HD) patients with chest pain and no acute ischemia on electrocardiogram (non-ST segment elevation myocardial infarction, non-STEMI). We sought to determine if cTnI elevation predicts significant CAD (>70% stenosis) in these patients. <i>Methods:<\/i> Ninety patients with non-STEMI referred for cardiac catheterization were included, divided equally into HD and non-HD groups. <i>Results:<\/i> Mean age and baseline characteristics were not significantly different between groups, except for left ventricular hypertrophy which was higher in HD patients (56 vs. 27%, p = 0.012). Initial cTnI correlated with obstructive CAD and was stratified into <0.3 and >0.3 ng\/ml. By logistic regression, cTnI >0.3 ng\/ml was not predictive of CAD in HD patients [odds ratio = 0.87 (95% CI 0.19\u20134.0), p = 0.8], while non-HD patients had an increased risk of CAD if first cTnI was >0.3 ng\/ml [odds ratio = 1.461 (95% CI 1.01\u20132.11), p = 0.04] as expected. Sensitivity, specificity, negative and positive predictive values of cTnI in predicting obstructive CAD were better in non-HD patients. <i>Conclusion:<\/i> cTnI in these patients had no predictive value for obstructive CAD. This contrasts with the general population, suggesting a higher index of suspicion for high-grade CAD irrespective of cTnI levels in HD patients.<\/jats:p>","DOI":"10.1159\/000235651","type":"journal-article","created":{"date-parts":[[2009,8,19]],"date-time":"2009-08-19T14:21:35Z","timestamp":1250691695000},"page":"292-297","source":"Crossref","is-referenced-by-count":4,"title":["Prediction of Hemodynamically Significant Coronary Artery Disease Using Troponin I in Hemodialysis Patients Presenting with Chest Pain: A Case-Control Study"],"prefix":"10.1159","volume":"114","author":[{"given":"Olurotimi J.","family":"Badero","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moro O.","family":"Salifu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,8,20]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199809173391203"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199610313351802"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2FS0735-1097%2898%2900176-4"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2FS0735-1097%2898%2900592-0"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2FS0735-1097%2801%2901513-3"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1161%2F01.CIR.0000095676.90936.80"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1093%2Fndt%2F17.10.1713"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1093%2Fndt%2F15.2.218"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199712043372302"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1093%2Fndt%2Fgfi125"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1161%2F01.CIR.0000041254.30637.34"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1161%2F01.CIR.102.16.1964"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2362.2007.01785.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2FS0009-9120%2898%2900089-7"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1093%2Fndt%2F15.8.1259"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1093%2Fndt%2Fgfg057"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1492-7535.2004.80406.x"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016%2FS0002-9149%2898%2900515-3"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1097%2F00002480-199809000-00021"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1515%2FCCLM.1998.016"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1097%2F00041552-199911000-00012"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1525-139x.2002.00090.x"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1553-2712.2004.tb00793.x"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.transproceed.2004.07.020"}],"container-title":["Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/235651","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/235651","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T22:08:20Z","timestamp":1745446100000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000235651"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009]]},"references-count":24,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2009,10,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000235651","archive":["Portico"],"relation":{},"ISSN":["0008-6312","1421-9751"],"issn-type":[{"type":"print","value":"0008-6312"},{"type":"electronic","value":"1421-9751"}],"subject":[],"published":{"date-parts":[[2009]]}}}