{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T23:58:10Z","timestamp":1777420690456,"version":"3.51.4"},"reference-count":22,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2009,12,22]],"date-time":"2009-12-22T00:00:00Z","timestamp":1261440000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,12,22]],"date-time":"2009-12-22T00:00:00Z","timestamp":1261440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digestion"],"published-print":{"date-parts":[[2010]]},"abstract":"<i>Background:<\/i> Endoscopic resection (endoscopic mucosal resection, EMR, and endoscopic submucosal dissection, ESD) has been accepted worldwide as a less invasive standard treatment for early gastric cancer (EGC). However, the risk of synchronous and metachronous gastric cancer developing in the post-endoscopic resection patient has become a major problem. We investigated the incidence and characteristics of synchronous and metachronous multiple gastric cancers in a retrospective study of patients with EGC after endoscopic resection. <i>Patients and Methods:<\/i> We studied the clinicopathological features of 235 patients with EGC who had undergone endoscopic resection and were periodically followed up using endoscopic examinations (181 with a single lesion, 34 synchronous multiple lesions, and 20 metachronous multiple lesions). <i>Results:<\/i> The overall incidence of synchronous and metachronous multiple gastric cancer was 14.5 and 8.5%, respectively, during a follow-up of 12\u201377 (median 26.5) months. Undifferentiated histology of the primary lesion was related to the occurrence of synchronous gastric cancer (p < 0.001). Undifferentiated histology and upper location of the primary lesion were correlated with the occurrence of metachronous gastric cancer (p = 0.002, 0.001). Most synchronous and metachronous lesions were well to moderately differentiated (82.4 and 80.0%); however, the proportion with undifferentiated histology (including poorly differentiated carcinoma and signet ring cell carcinoma) in synchronous and metachronous gastric cancer was significantly higher than in single gastric cancer (p = 0.008). <i>Conclusions:<\/i> Undifferentiated histology of EGC may predict the occurrence of synchronous and metachronous lesions after endoscopic resection.<\/jats:p>","DOI":"10.1159\/000235921","type":"journal-article","created":{"date-parts":[[2009,12,23]],"date-time":"2009-12-23T08:12:31Z","timestamp":1261555951000},"page":"35-42","source":"Crossref","is-referenced-by-count":37,"title":["Undifferentiated Histology after Endoscopic Resection May Predict Synchronous and Metachronous Occurrence of Early Gastric Cancer"],"prefix":"10.1159","volume":"81","author":[{"given":"Ju Hee","family":"Seo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun Chul","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu Jin","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung Kwan","family":"Shin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong Chan","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang Kil","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,12,22]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1055%2Fs-2005-870198"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1097%2F00004836-199807000-00012"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1159%2F000055360"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002%2F1097-0142%2820001001%2989%3A7%3C1425%3A%3AAID-CNCR3%3E3.0.CO%3B2-7"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007%2FPL00011720"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291097-0142%2819960215%2977%3A4%3C602%3A%3AAID-CNCR3%3E3.0.CO%3B2-I"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291097-0142%2819990515%2985%3A10%3C2119%3A%3AAID-CNCR4%3E3.0.CO%3B2-M"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007%2Fs10120-006-0372-9"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002%2F1097-0142%2819900601%2965%3A11%3C2602%3A%3AAID-CNCR2820651134%3E3.0.CO%3B2-8"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002%2F1097-0142%2819870201%2959%3A3%3C560%3A%3AAID-CNCR2820590334%3E3.0.CO%3B2-G"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002%2Fbjs.1800821127"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1002%2Fbjs.1800760308"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1136%2Fgut.2008.165381"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1097%2F00004836-199907000-00011"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1002%2Fcncr.10120"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016%2FS0748-7983%2803%2900094-5"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1002%2F1097-0142%2819920401%2969%3A7%3C1645%3A%3AAID-CNCR2820690702%3E3.0.CO%3B2-X"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1620%2Ftjem.186.121"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291097-0142%2819961115%2978%3A10%3C2078%3A%3AAID-CNCR7%3E3.0.CO%3B2-K"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00464-008-0317-y"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2808%2961159-9"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1055%2Fs-2007-1008990"}],"container-title":["Digestion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/235921","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/235921","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T22:10:28Z","timestamp":1745446228000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000235921"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,12,22]]},"references-count":22,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2010,2,1]]},"published-print":{"date-parts":[[2010,2,25]]}},"URL":"https:\/\/doi.org\/10.1159\/000235921","archive":["Portico"],"relation":{},"ISSN":["0012-2823","1421-9867"],"issn-type":[{"value":"0012-2823","type":"print"},{"value":"1421-9867","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,12,22]]}}}