{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T02:46:19Z","timestamp":1778899579526,"version":"3.51.4"},"reference-count":15,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2009,9,2]],"date-time":"2009-09-02T00:00:00Z","timestamp":1251849600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,9,2]],"date-time":"2009-09-02T00:00:00Z","timestamp":1251849600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ophthalmologica"],"published-print":{"date-parts":[[2010]]},"abstract":"<i>Aims:<\/i> To evaluate retinal nerve fiber layer (RNFL) thickness in eyes with Graves\u2019 orbitopathy (GO), in eyes with ocular hypertension (OHT) and in a control group of healthy eyes. <i>Methods:<\/i> Observational, controlled cross-sectional study. We evaluated all patients with primary open-angle glaucoma (POAG) and all patients with GO and intraocular pressure >23 mm Hg in primary position examined from March 2006 to June 2007. Forty apparently healthy patients (80 eyes) were enrolled as a control group. Complete ophthalmic evaluation, visual field (VF) examination with the Humphrey Visual Field Analyzer and RNFL thickness measurement with optic nerve tracking optical coherence tomography (ONT-OCT; OCT\/SLO, OTI, Toronto, Ont., Canada) were performed. <i>Results:<\/i> Among 116 eyes with POAG [58 patients, 32 males, 26 females, mean age 62 (46\u201371) years], RNFL was reduced in 87 eyes (75%, p = 0.05) when compared with the control group, and a good correlation was found between RNFL thickness and VF abnormalities (Spearman\u2019s \u03c1 0.822; p = 0.001). Among 60 eyes [30 patients, 12 males, 18 females, mean age 56 (50\u201369) years] with GO and OHT, nonglaucomatous diffuse abnormalities of the VF were detected in 44 eyes (73.3%, p = 0.03), while RNFL thinning was present in 14 eyes (9 patients, 23.3%, p = 0.03). No correlation was found between RNFL thickness and VF abnormalities (Spearman\u2019s \u03c1 0.365; p = 0.02). No significant differences in RNFL pattern were present between the group with GO, OHT and RNFL thinning and the group with POAG. <i>Conclusions:<\/i> In patients with GO and OHT, evaluation of RNFL thickness with ONT-OCT may represent an objective diagnostic technique for detecting optic neuropathy.<\/jats:p>","DOI":"10.1159\/000235925","type":"journal-article","created":{"date-parts":[[2009,9,4]],"date-time":"2009-09-04T13:04:16Z","timestamp":1252069456000},"page":"116-121","source":"Crossref","is-referenced-by-count":38,"title":["Evaluation of Retinal Nerve Fiber Layer with Optic Nerve Tracking Optical Coherence Tomography in Thyroid-Associated Orbitopathy"],"prefix":"10.1159","volume":"224","author":[{"given":"Raimondo","family":"Forte","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Bonavolont\u00e0","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrizia","family":"Vassallo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,9,2]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1159%2F000307046"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1755-3768.1973.tb06025.x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2FS0002-9394%2802%2902003-2"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.eye.6702448"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1167%2Fiovs.05-0748"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1097%2FIJG.0b013e31802e644b"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097%2F01.ijg.0000212215.12180.19"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ophtha.2004.10.020"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097%2FIJG.0b013e318032e4d4"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2FS0002-9394%2801%2901340-X"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ophtha.2007.03.005"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1167%2Fiovs.07-1127"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1136%2Fbjo.2006.094607"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1167%2Fiovs.06-0327"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2FS0161-6420%2800%2900477-2"}],"container-title":["Ophthalmologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/235925","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/235925","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T22:10:30Z","timestamp":1745446230000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000235925"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,9,2]]},"references-count":15,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2010,2,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000235925","archive":["Portico"],"relation":{},"ISSN":["0030-3755","1423-0267"],"issn-type":[{"value":"0030-3755","type":"print"},{"value":"1423-0267","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,9,2]]}}}