{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T13:42:35Z","timestamp":1777902155779,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2009,9,3]],"date-time":"2009-09-03T00:00:00Z","timestamp":1251936000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2009,9,3]],"date-time":"2009-09-03T00:00:00Z","timestamp":1251936000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Immunol"],"abstract":"<jats:p>Several adhesion molecules and CD45RO have been reported to be upregulated on the cell surface of \u2018memory\u2019 T cells. Using triple-color flow cytometry, we compared the levels of typical \u2018memory\u2019 cell markers on peripheral blood T-cell subpopulations in a number of kidney transplant recipients, patients with systemic lupus erythematosus, newborn infants and healthy donors. CD45RO, VLA-\u03b21 (CD29), VLA-5\u03b1 (CD49e), LFA-1 (CD11a\/18), and CD2 were found to be closely coregulated on CD4+ T cells, while regulation of VLA-2\u03b1 (Cd49b), VLA-4\u03b1 (CD49d) and CD44 was quite discordant. In CD8+ T cells, by contrast, multiple subsets of \u2018memory\u2019-type cells were distinguished. Unlike TCR \u03b1\/\u03b2 T cells, which expressed either high or low levels of LFA-1, TCR \u03b3\/\u03b4 cells all expressed high levels of LFA-1 (CD11a\/CD18). Examination of T cells from kidney graft fine-needle aspiration biopsies during rejection revealed intragraft accumulation of \u2018memory\u2019-type T cells expressing high levels of CD2 and LFA-1 (CD11a\/CD18). Regarding peripheral blood T-cell subsets, differences between patients and healthy controls were only of a quantitative nature.<\/jats:p>","DOI":"10.1159\/000236704","type":"journal-article","created":{"date-parts":[[2009,9,4]],"date-time":"2009-09-04T09:04:16Z","timestamp":1252055056000},"page":"17-26","source":"Crossref","is-referenced-by-count":18,"title":["Discordant Expression of LFA-1 VLA-4\u03b1, VLA-\u03b21, CD45RO and CD28 on T-Cell Subsets: Evidence for Multiple Subsets of \u2018Memory\u2019 T Cells"],"prefix":"10.1159","author":[{"given":"F.","family":"Kern","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.D.","family":"D\u00f6cke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Reinke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.D.","family":"Volk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,9,3]]},"container-title":["International Archives of Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/236704","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000236704","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T11:21:33Z","timestamp":1777634493000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000236704"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,9,3]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000236704","archive":["Portico"],"relation":{},"ISSN":["1018-2438","1423-0097"],"issn-type":[{"value":"1018-2438","type":"print"},{"value":"1423-0097","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,9,3]]}}}