{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T08:51:22Z","timestamp":1784191882444,"version":"3.55.0"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2009,9,3]],"date-time":"2009-09-03T00:00:00Z","timestamp":1251936000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2009,9,3]],"date-time":"2009-09-03T00:00:00Z","timestamp":1251936000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Immunol"],"abstract":"<jats:p>The serum levels of the four subclasses of IgG to three different antigens \u2013 ovalbumin (OVA), pneumococcal polysaccharide (PNC), and avidin \u2013 were determined by enzyme-linked immunosorbent assay in three age groups of healthy children: 1.2-2.5 years (group A, n = 20), 6-7 years (group B, n = 21) and 15-17 years (group C, n = 20). The anti-OVA response in all groups was dominated by IgG1, IgG2, and IgG4 antibodies which generally increased in levels from group A to group B, but then declined significantly in group C. In all age groups, the IgG2 and IgG4 as well as the IgG1 and IgG3 responses were correlated; an association was also observed between IgG1 and IgG2 in groups B and C, but not in group A. The anti-PNC response was restricted to the IgG2 and IgG4 subclasses; correlation between these subclasses was seen only in group B children. The more predominant IgG2 antibodies increased dramatically in concentration from group A to group B, and then less remarkably in group C. Occurrence of the IgG1 anti-PNC antibodies was different which resembled the anti-OVA response. Responses to avidin, a protein derived from the same source as OVA, were different from the anti-OVA responses. These were low and confined to the IgG1 and IgG2 subclasses only and mainly to the younger children. A small group (n = 8) of 6- to 7-year-old atopic children who had a history of asthma or eczema appeared to have responses similar to their healthy counterparts.<\/jats:p>","DOI":"10.1159\/000236721","type":"journal-article","created":{"date-parts":[[2009,9,15]],"date-time":"2009-09-15T08:17:46Z","timestamp":1253002666000},"page":"137-143","source":"Crossref","is-referenced-by-count":10,"title":["Occurrence of IgG Subclass Antibodies to Ovalbumin, Avidin, and Pneumococcal Polysaccharide in Children"],"prefix":"10.1159","author":[{"given":"Pak Leong","family":"Lim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu Lung","family":"Lau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2009,9,3]]},"container-title":["International Archives of Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/236721","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000236721","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T11:21:53Z","timestamp":1777634513000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000236721"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,9,3]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000236721","archive":["Portico"],"relation":{},"ISSN":["1018-2438","1423-0097"],"issn-type":[{"value":"1018-2438","type":"print"},{"value":"1423-0097","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,9,3]]}}}