{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T17:25:48Z","timestamp":1775582748661,"version":"3.50.1"},"reference-count":30,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dement Geriatr Cogn Disord"],"published-print":{"date-parts":[[2009]]},"abstract":"<jats:p>&lt;i&gt;Background\/Aim:&lt;\/i&gt; Midlife high blood pressure is linked to late-life dementia. We sought to investigate the temporal relation of blood pressure to the risk of dementia and Alzhei-mer\u2019s disease (AD) among older adults. &lt;i&gt;Methods:&lt;\/i&gt; A dementia-free cohort (n = 422) aged \u226581 years was followed for 3 years to detect dementia and AD cases (Diagnostic and Statistical Manual of Mental Disorders, Third Edition, Revised criteria). The blood pressure was measured 4 times over a 9-year period starting from \u226575 years of age. The data were analyzed with Cox models controlling for potential confounders. &lt;i&gt;Results:&lt;\/i&gt; During the 954 person-years of follow- up, 89 subjects developed dementia (72 AD cases). Low diastolic pressure (&lt;70 vs. 70\u201389 mm Hg) was associated with a multiadjusted hazard ratio of 2.13 [95% confidence interval (CI) = 1.05\u20134.32] for dementia and 2.16 (95% CI = 0.98\u20134.73) for AD occurring over a 6-to 9-year period, whereas high diastolic pressure (\u226590 mm Hg) was marginally related to a decreased hazard ratio of 0.58 (95% CI = 0.33\u20131.02) for dementia and 0.57 (95% CI = 0.30\u20131.09) for AD. Systolic pressure was not significantly related to dementia risk. Subjects who developed dementia had a greater decline in blood pressure than persons who did not, mainly during the 3-year period before dementia diagnosis. &lt;i&gt;Conclusion:&lt;\/i&gt; Low diastolic pressure predicts the risk of dementia among very old people, and the blood pressure exhibits a substantial decline over around 3 years before the dementia syndrome becomes clinically evident.<\/jats:p>","DOI":"10.1159\/000236913","type":"journal-article","created":{"date-parts":[[2009,9,11]],"date-time":"2009-09-11T13:12:33Z","timestamp":1252674753000},"page":"213-219","source":"Crossref","is-referenced-by-count":61,"title":["Low Diastolic Pressure and Risk of Dementia in Very Old People: A Longitudinal Study"],"prefix":"10.1159","volume":"28","author":[{"given":"Chengxuan","family":"Qiu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bengt","family":"Winblad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Fratiglioni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,9,12]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2FS1474-4422%2805%2970141-1"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1001%2Farchneur.62.1.112"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1532-5415.2007.01233.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2FS0197-4580%2800%2900096-8"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1136%2Fbmj.322.7300.1447"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1212%2F01.WNL.0000149519.47454.F2"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1159%2F000051233"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1001%2Farchneur.58.10.1640"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1159%2F000089235"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2896%2990608-X"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1001%2Farchneur.60.2.223"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2F0165-1838%2894%2990160-0"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1136%2Fjnnp.2003.021493"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1532-5415.2007.01458.x"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1161%2F01.STR.0000060127.96986.F4"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1161%2F01.STR.0000133128.42462.ef"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1212%2F01.wnl"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1159%2F000094973"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1161%2F01.STR.0000052631.98405.15"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMoa022066"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1161%2F01.HYP.0000145857.98904.20"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1212%2F01.WNL.0000149641.55751.2E"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1001%2Farchneur.61.10.1531"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1212%2F01.wnl.0000308937.30473.d1"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1159%2F000078503"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1002%2Fana.20493"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1159%2F000160955"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00401-006-0136-y"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1161%2FCIRCULATIONAHA.106.686477"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1002%2Fana.21073"}],"container-title":["Dementia and Geriatric Cognitive Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/236913","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/236913","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T22:22:34Z","timestamp":1745446954000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000236913"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009]]},"references-count":30,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2009,10,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000236913","archive":["Portico"],"relation":{},"ISSN":["1420-8008","1421-9824"],"issn-type":[{"value":"1420-8008","type":"print"},{"value":"1421-9824","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009]]}}}