{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T15:05:13Z","timestamp":1777907113075,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2009,9,4]],"date-time":"2009-09-04T00:00:00Z","timestamp":1252022400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2009,9,4]],"date-time":"2009-09-04T00:00:00Z","timestamp":1252022400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Immunol"],"abstract":"<jats:p>For the purpose of evaluating the roles of IgE in helminth infections in vivo, IgE-suppressed mice provide useful models. After infection with 50 third-stage larvae of the filarial parasite Brugia malayi, total IgE in BALB\/c mice increased to five times higher than uninfected levels. However, anti-B. malayi IgE antibody was not detected, indicating polyclonal IgE B cell activation by the infection. In BALB\/c mice which had received repeated injections of anti-mouse \u03b5 monoclonal antibody from birth and which were subsequently infected, total IgE levels were less than 10 ng\/ml, but anti-B. malayi IgG antibody and total IgA were produced similar to the control. Therefore, IgE-isotype-specific suppression was attained. Concerning the protection against B. malayi, the numbers of fourth-stage larvae and adult worms at 2 and 5 weeks after primary infection, respectively, and fourth-stage larvae at 2 weeks after secondary infection were not significantly different between control and IgE-suppressed mice.<\/jats:p>","DOI":"10.1159\/000237219","type":"journal-article","created":{"date-parts":[[2009,9,4]],"date-time":"2009-09-04T09:04:16Z","timestamp":1252055056000},"page":"192-196","source":"Crossref","is-referenced-by-count":7,"title":["Brugia malayi Infection in Mice with Selective Suppression of IgE Production"],"prefix":"10.1159","author":[{"given":"Naohiro","family":"Watanabe","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiro","family":"Hayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akio","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Ohtomo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,9,4]]},"container-title":["International Archives of Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/237219","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000237219","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T13:29:54Z","timestamp":1777642194000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000237219"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,9,4]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000237219","archive":["Portico"],"relation":{},"ISSN":["1018-2438","1423-0097"],"issn-type":[{"value":"1018-2438","type":"print"},{"value":"1423-0097","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,9,4]]}}}