{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T20:44:01Z","timestamp":1778705041277,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2009,9,4]],"date-time":"2009-09-04T00:00:00Z","timestamp":1252022400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2009,9,4]],"date-time":"2009-09-04T00:00:00Z","timestamp":1252022400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Immunol"],"abstract":"<jats:p>Hapten-specific and mast-cell-dependent biphasic (immediate and delayed-onset) cutaneous reactions were induced in a murine model by intravenous injection of anti-DNP IgE antibodies followed by a skin test. Four daily applications of topical 1\u03b1,24(OH)&lt;sub&gt;2&lt;\/sub&gt;D&lt;sub&gt;3&lt;\/sub&gt; ointment significantly inhibited both the immediate and the delayed-onset cutaneous reactions in a dose-dependent fashion, as well as the croton-oil-induced cutaneous reaction and DNFB contact sensitivity reaction. 1\u03b1,24(OH)&lt;sub&gt;2&lt;\/sub&gt;D&lt;sub&gt;3&lt;\/sub&gt; itself did not show any sensitizing or irritant potential. The inhibitory effect of 1\u03b1,24(OH)&lt;sub&gt;2&lt;\/sub&gt;D&lt;sub&gt;3&lt;\/sub&gt; on these reactions was limited to the application site and no systemic effect was observed. Another vitamin D&lt;sub&gt;3&lt;\/sub&gt; analog 1\u03b1,25(OH)&lt;sub&gt;2&lt;\/sub&gt;D&lt;sub&gt;3&lt;\/sub&gt;, also showed an inhibitory effect on IgE-mediated cutaneous reactions. These results suggest that topically applied 1\u03b1,24(OH)&lt;sub&gt;2&lt;\/sub&gt;D&lt;sub&gt;3&lt;\/sub&gt; might modulate IgE-mediated cutaneous reactions and could thus be useful in the treatment of certain human cutaneous disorders other than psoriasis and related keratinizing disorders.<\/jats:p>","DOI":"10.1159\/000237348","type":"journal-article","created":{"date-parts":[[2009,9,15]],"date-time":"2009-09-15T08:17:46Z","timestamp":1253002666000},"page":"71-76","source":"Crossref","is-referenced-by-count":19,"title":["Topical Vitamin D\n                    <sub>3<\/sub>\n                    Downregulates IgE-Mediated Murine Biphasic Cutaneous Reactions"],"prefix":"10.1159","author":[{"given":"Ichiro","family":"Katayama","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuya","family":"Minatohara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroo","family":"Yokozeki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiyoshi","family":"Nishioka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,9,4]]},"container-title":["International Archives of Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/237348","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000237348","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T13:31:05Z","timestamp":1777642265000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000237348"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,9,4]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000237348","archive":["Portico"],"relation":{},"ISSN":["1018-2438","1423-0097"],"issn-type":[{"value":"1018-2438","type":"print"},{"value":"1423-0097","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,9,4]]}}}