{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T15:08:52Z","timestamp":1777907332846,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2009,9,4]],"date-time":"2009-09-04T00:00:00Z","timestamp":1252022400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2009,9,4]],"date-time":"2009-09-04T00:00:00Z","timestamp":1252022400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Immunol"],"abstract":"Background: Cysteinyl leukotrienes (LTs) and thromboxane A<sub>2<\/sub> (TXA<sub>2<\/sub>) are known to play an essential role in the pathogenesis of atopic asthma. However, their role in nonatopic asthma has not as yet been clarified. The objectives of this study were to define (1) the participation of LTs and TXA<sub>2<\/sub> in nonatopic asthma and (2) the relationship between LTs and TXA<sub>2<\/sub> in asthma attacks. Methods: Urinary excretion of leukotriene E<sub>4<\/sub> (LTE<sub>4<\/sub>) and 11-dehydrothromboxane B<sub>2<\/sub> (11DTXB<sub>2<\/sub>) was measured in 10 atopic and 10 nonatopic asthmatics who were admitted to hospital with either an acute asthma attack or status asthmaticus. Results: In atopic asthmatics, urinary excretion of LTE<sub>4<\/sub> and 11DTXB<sub>2<\/sub> was significantly higher on admission with an asthma attack, and returned to control levels when the patients were in the improved state (179\u00b129 to 65\u00b116 ng\/day in LTE4,1,085\u00b1250 to 440\u00b190 ng\/day in 11DTXB<sub>2<\/sub>). Similar findings were observed in nonatopic asthmatics (148\u00b113 to 61\u00b111 ng\/day in LTE4,1,089\u00b1206 to 457\u00b160 ng\/day in 11DTXB<sub>2<\/sub>). However, when the individual data during the attack were analyzed, there was no correlation between urinary excretion of LTE<sub>4<\/sub> and that of 11DTXB<sub>2<\/sub> in both types of asthma. Conclusion: Both LTs and TXA<sub>2<\/sub> may be implicated in the pathogenesis of the nonatopic as well as the atopic type of asthma, but no correlation between these two metabolites was observed in the individuals.<\/jats:p>","DOI":"10.1159\/000237697","type":"journal-article","created":{"date-parts":[[2009,9,15]],"date-time":"2009-09-15T08:17:46Z","timestamp":1253002666000},"page":"373-378","source":"Crossref","is-referenced-by-count":25,"title":["Urinary Excretion of Leukotriene E\n 4<\/sub>\n and 11-Dehydrothromboxane B\n 2<\/sub>\n in Patients with Spontaneous Asthma Attacks"],"prefix":"10.1159","author":[{"given":"Rokuo","family":"Oosaki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yutaka","family":"Mizushima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Kawasaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuhiko","family":"Kashii","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haruhisa","family":"Mita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takao","family":"Shida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuo","family":"Akiyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masashi","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,9,4]]},"container-title":["International Archives of Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/237697","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000237697","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T13:34:06Z","timestamp":1777642446000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000237697"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,9,4]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000237697","archive":["Portico"],"relation":{},"ISSN":["1018-2438","1423-0097"],"issn-type":[{"value":"1018-2438","type":"print"},{"value":"1423-0097","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,9,4]]}}}