{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T01:53:18Z","timestamp":1776563598248,"version":"3.51.2"},"reference-count":24,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Surg Res"],"published-print":{"date-parts":[[2009]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; The aim of this study was to investigate the effect of low-pressure pneumoperitoneum and pentoxifylline, a methylxanthine derivative, in the prevention of injury caused by free oxygen radicals generated during CO&lt;sub&gt;2 &lt;\/sub&gt;pneumoperitoneum. &lt;i&gt;Methods:&lt;\/i&gt; Twenty-eight rabbits were allocated randomly to 4 groups. Control group rabbits (group 1) were subjected to anesthesia for 60 min; group 2 and 3 animals were subjected to a CO&lt;sub&gt;2&lt;\/sub&gt; pneumoperitoneum (15 or 7 mm Hg); and group 4 rabbits received 50 mg\/kg pentoxifylline, followed by a 15-mm-Hg pneumoperitoneum. Serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), lipid hydroperoxide, glutathione reductase and total antioxidant status were measured. &lt;i&gt;Results:&lt;\/i&gt; Compared with group 1, a significant increase in lipid hydroperoxide levels at the end of the pneumoperitoneum and 30 min after deflation and a significant decrease in total antioxidant status 24 h after deflation were recorded in group 2. In addition, a significant increase was observed in ALT, AST and LDH levels. These changes were attenuated by low-pressure pneumoperitoneum, whereas pentoxifylline pretreatment appeared to attenuate only transaminase levels. &lt;i&gt;Conclusion:&lt;\/i&gt; Low-pressure pneumoperitoneum could attenuate ischemia\/reperfusion injury induced by CO&lt;sub&gt;2 &lt;\/sub&gt;pneumoperitoneum in a rabbit model whereas pentoxifylline pretreatment appeared to attenuate only transaminase levels. Pentoxifylline did not prevent the development of oxidative stress.<\/jats:p>","DOI":"10.1159\/000237747","type":"journal-article","created":{"date-parts":[[2009,9,16]],"date-time":"2009-09-16T16:41:14Z","timestamp":1253119274000},"page":"330-337","source":"Crossref","is-referenced-by-count":11,"title":["Comparison of the Effects of Low Intra-Abdominal Pressure and Pentoxifylline on Oxidative Stress during CO&lt;sub&gt;2&lt;\/sub&gt; Pneumoperitoneum in Rabbits"],"prefix":"10.1159","volume":"43","author":[{"given":"V.","family":"Nesek-Adam","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Vnuk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u017d.","family":"Ra\u0161i\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Rumenjak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Kos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z.","family":"Krstonijevi\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,9,16]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1007%2FBF00187381"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1097%2F00005373-199208000-00019"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007%2Fs002689900002"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1080%2F11024159950189384"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007%2Fs004640000168"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00464-002-9258-z"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.2165%2F00003495-198734010-00003"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1097%2F00003246-199105000-00021"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2FS0039-6060%2897%2990106-9"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007%2Fs004649900758"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.0001-5172.2004.00431.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007%2Fs11605-008-0557-0"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1093%2Fhumrep%2Fdeh380"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1089%2F1092642041255450"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1159%2F000101009"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1159%2F000008767"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00268-004-7172-3"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1006%2Fjsre.1997.5132"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1007%2FBF00314976"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1159%2F000049719"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1097%2F00007890-199506150-00006"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00464"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016%2FS0009-9120%2899%2900041-7"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1097%2F00003246-199602000-00014"}],"container-title":["European Surgical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/237747","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/237747","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T22:32:39Z","timestamp":1745447559000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000237747"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009]]},"references-count":24,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2009,11,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000237747","archive":["Portico"],"relation":{},"ISSN":["0014-312X","1421-9921"],"issn-type":[{"value":"0014-312X","type":"print"},{"value":"1421-9921","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009]]}}}