{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T23:51:49Z","timestamp":1777765909887,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2009,9,8]],"date-time":"2009-09-08T00:00:00Z","timestamp":1252368000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2009,9,8]],"date-time":"2009-09-08T00:00:00Z","timestamp":1252368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chemotherapy"],"abstract":"<jats:p>The study was carried out with 50 strains of gonococci. Susceptibility to the antibiotics was determined by standard sensitivity test, by systematic test for \u03b2-lactamase and by measurement of the MICs. The cephalosporins tested were: moxalactam, cefotaxime, ceftriaxone, cefotiam, cefoxitin, cefazolin and cephalothin. Their activities were also compared with other \u03b2-lactams, namely penicillin and ampicillin. The efficacy in vitro of the cephalosporins: in the lead, ceftriaxone, remarkably active, with cefotaxime following very close, and then moxalactam with cefotiam a little behind, and finally all the other \u03b2-lactams tested. The median MICs of the new cephalosporins (moxalactam, cefotaxime, ceftriaxone and cefotiam) were at least 10 times greater than those of the other \u03b2-lactams tested. The MIC values observed with a resistant strain (penicillin, ampicillin; MIC 256 \u03bcg\/ml) never exceed the maximum values found with the 50 susceptible strains.<\/jats:p>","DOI":"10.1159\/000238023","type":"journal-article","created":{"date-parts":[[2009,9,9]],"date-time":"2009-09-09T09:21:59Z","timestamp":1252488119000},"page":"15-18","source":"Crossref","is-referenced-by-count":0,"title":["Study of the in vitro Activity of New Cephalosporins on Strains of Neisseria gonorrhoeaeof the Toulouse Region"],"prefix":"10.1159","author":[{"given":"M.F.","family":"Pr\u00e8re","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.C.","family":"Lef\u00e8vre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.B.","family":"Lareng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,9,8]]},"container-title":["Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/238023","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000238023","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T15:30:26Z","timestamp":1777476626000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000238023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,9,8]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000238023","archive":["Portico"],"relation":{},"ISSN":["0009-3157","1421-9794"],"issn-type":[{"value":"0009-3157","type":"print"},{"value":"1421-9794","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,9,8]]}}}