{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T23:57:42Z","timestamp":1777766262338,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2009,9,8]],"date-time":"2009-09-08T00:00:00Z","timestamp":1252368000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2009,9,8]],"date-time":"2009-09-08T00:00:00Z","timestamp":1252368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chemotherapy"],"abstract":"<jats:p>The concentrations of trimethoprim (TMP), sulfadiazine (SD) and acetyl-SD in serum and maxillary sinus secretions of 10 patients with acute maxillary sinusitis were measured at the steady-state of continuous b.i.d. treatment with 160 mg of TMP + 500 mg of SD. The samples were collected 2\u20134 h after the preceding dose of TMP\/SD. The mean TMP concentrations were 2.97 \u00b1 0.35 \u00b5g\/ml (mean + SE) and 3.85 \u00b1 1.12 \u00b5g\/ml in serum and sinus secretion, respectively. The average sinus secretion\/serum ratio was 1.33. The mean SD levels in serum and sinus secretion were 41.9 \u00b1 4.5 and 6.64 \u00b1 1.40 \u00b5g\/ml, respectively, and the average sinus secretion\/serum ratio was 0.20. Most patients (7\/10) had detectable amounts of acetyl-SD in sinus secretions (mean 1.92 \u00b1 0.87 \u00b5g\/ml). The corresponding concentrations in serum were 4.56 \u00b1 0.47 \u00b5g\/ml.<\/jats:p>","DOI":"10.1159\/000238193","type":"journal-article","created":{"date-parts":[[2009,9,9]],"date-time":"2009-09-09T09:21:59Z","timestamp":1252488119000},"page":"174-177","source":"Crossref","is-referenced-by-count":0,"title":["Penetration of Trimethoprim and Sulfadiazine into Sinus Secretion in Acute Maxillary Sinusitis"],"prefix":"10.1159","author":[{"given":"J.","family":"Mattila","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.T.","family":"M\u00e4nnist\u00f6","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Luodeslampi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,9,8]]},"container-title":["Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/238193","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000238193","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T15:32:39Z","timestamp":1777476759000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000238193"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,9,8]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000238193","archive":["Portico"],"relation":{},"ISSN":["0009-3157","1421-9794"],"issn-type":[{"value":"0009-3157","type":"print"},{"value":"1421-9794","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,9,8]]}}}