{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T18:25:58Z","timestamp":1768674358233,"version":"3.49.0"},"reference-count":14,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2009]]},"abstract":"<i>Background:<\/i> Regulatory T-cell (T<sub>reg<\/sub>) modulation is one of the potential mechanisms of anti-tumour-necrosis-factor biological agents. However, literature data on psoriasis patients are lacking. <i>Objective:<\/i> To analyse the circulating CD4+CD25<sup>bright<\/sup>FOXP3+ subset in 30 patients with psoriasis vulgaris\/arthropathic psoriasis treated with biologicals and to investigate its relationship with the clinical response. <i>Methods:<\/i> The CD25<sup>bright<\/sup>FOXP3+ expression within the CD4+ subset was determined by multi-parameter flow cytometry at baseline and during treatment. FOXP3 mRNA expression was analysed by real-time reverse transcription PCR. <i>Results:<\/i> A response was obtained in 16\/17 patients (91.1%) with increased CD25<sup>bright<\/sup>FOXP3+ values and in only 3\/11 patients (27.3%) who showed a CD25<sup>bright<\/sup>FOXP3+ decrease during biological treatment (p = 0.0001). Responders showed significantly higher values than did non-responders as from the first 2 months of treatment (p = 0.0032). A significantly higher posttreatment expression of mRNA FOXP3 was observed in responders compared to non-responders. <i>Conclusion:<\/i> Biological drugs induce a circulating T<sub>reg<\/sub> up-regulation in a significant percentage of patients; such an increase is an early predictive marker of response.<\/jats:p>","DOI":"10.1159\/000238305","type":"journal-article","created":{"date-parts":[[2009,9,11]],"date-time":"2009-09-11T13:12:50Z","timestamp":1252674770000},"page":"250-258","source":"Crossref","is-referenced-by-count":41,"title":["Circulating CD4+CD25<sup>bright<\/sup>FOXP3+ T Cells Are Up-Regulated by Biological Therapies and Correlate with the Clinical Response in Psoriasis Patients"],"prefix":"10.1159","volume":"219","author":[{"given":"P.","family":"Quaglino","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Ortoncelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Comessatti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Ponti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Novelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Bergallo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Costa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Cicchelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Savoia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.G.","family":"Bernengo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,9,11]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.autrev.2006.12.002"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1001%2Farchderm.138.5.657"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.molmed.2007.01.003"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1182%2Fblood-2005-11-4567"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1084%2Fjem.20061531"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1084%2Fjem.20040165"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2567.2008.02839.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1159%2F000093849"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2133.2008.08504.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1369%2Fjhc.6A7119.2007"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jdermsci.2008.04.015"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jdermsci.2008.09.011"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.humimm.2004.09.004"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2249.2005.02754.x"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/238305","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/238305","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T21:53:05Z","timestamp":1745445185000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000238305"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009]]},"references-count":14,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2009,10,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000238305","archive":["Portico"],"relation":{},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"value":"1018-8665","type":"print"},{"value":"1421-9832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009]]}}}