{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T01:36:20Z","timestamp":1785461780563,"version":"3.56.0"},"reference-count":18,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Nephrol"],"published-print":{"date-parts":[[2009]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Uric acid has been reported to be a risk factor for the development of chronic kidney disease; however, no study has examined whether uric acid may confer a risk for acute kidney injury. &lt;i&gt;Methods:&lt;\/i&gt; We investigated the relation between serum uric acid and the incidence of postoperative acute kidney injury in patients undergoing high-risk cardiovascular surgery (cardiac valve and aneurysm surgery). &lt;i&gt;Results:&lt;\/i&gt; Following cardiovascular surgery, 18 of 58 patients (31%) developed acute kidney injury, with 11 of 24 (45.8%) in the elevated uric acid group (defined as &gt;6 mg\/dl) and 7 of 34 (20.5%) in the normal uric acid group (p = 0.05). After controlling for baseline renal function, left ventricular ejection fraction, use of nesiritide, type of surgery, and history of previous surgery, an elevated preoperative uric acid conferred a 4-fold risk for acute kidney injury (OR: 3.98, CI: 1.10\u201314.33, p = 0.035) and longer hospital stay (36.35 vs. 24.66 days, p = 0.009). &lt;i&gt;Conclusion:&lt;\/i&gt; This preliminary study suggests that uric acid may be a novel risk factor for acute kidney injury in patients undergoing high-risk cardiovascular surgery.<\/jats:p>","DOI":"10.1159\/000238824","type":"journal-article","created":{"date-parts":[[2009,9,11]],"date-time":"2009-09-11T13:12:33Z","timestamp":1252674753000},"page":"425-429","source":"Crossref","is-referenced-by-count":44,"title":["Uric Acid: A Novel Risk Factor for Acute Kidney Injury in High-Risk Cardiac Surgery Patients?"],"prefix":"10.1159","volume":"30","author":[{"given":"A. Ahsan","family":"Ejaz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas M.","family":"Beaver","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michiko","family":"Shimada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Puneet","family":"Sood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijaykumar","family":"Lingegowda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesse D.","family":"Schold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tad","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2009,9,11]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1377%2Fhlthaff.26.1.162"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007%2Fs10016-001-0181-x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097%2F00000539-199712000-00009"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2FS0741-5214%2896%2970189-1"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2FS0002-9343%2898%2900058-8"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1291%2Fhypres.24.691"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1681%2FASN.2008010080"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1186%2Fcc5713"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.2215%2FCJN.01890408"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.2215%2FCJN.04271007"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1523-1755.2005.00074.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2FS0272-6386%2804%2900934-5"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.2215%2FCJN.04271007"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1161%2F01.CIR.0000065637.10517.A0"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1097%2FMNH.0b013e328305b9a5"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.2215%2FCJN.00350106"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.amjcard.2008.05.019"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1152%2Fajprenal.00160.2006"}],"container-title":["American Journal of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/238824","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/238824","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T21:58:38Z","timestamp":1745445518000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000238824"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009]]},"references-count":18,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2009,11,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000238824","archive":["Portico"],"relation":{},"ISSN":["0250-8095","1421-9670"],"issn-type":[{"value":"0250-8095","type":"print"},{"value":"1421-9670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009]]}}}