{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T00:23:19Z","timestamp":1777767799952,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2009,9,11]],"date-time":"2009-09-11T00:00:00Z","timestamp":1252627200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2009,9,11]],"date-time":"2009-09-11T00:00:00Z","timestamp":1252627200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chemotherapy"],"abstract":"<jats:p>Xanthomonas maltophilia produces two inducible \u03b2-lactamases, L-1 and L-2, and resists the antimicrobial activity of \u03b2-lactam antibiotics including carbapenems. L-1 has carbapenemase activity and L-2 is a cephalosporinase. It has been suggested that these \u03b2-lactamases share regulatory components. We isolated a recent clinical X. maltophilia strain susceptible to carbapenems and resistant to almost all the other \u03b2-lactam antibiotics tested. \u03b2-Lactamase induction with cefotaxime showed that the clinical isolate had low-level expression of L-1 \u03b2-lactamase but remained inducible for L-2 enzyme. The possible relationship of this enzyme to carbapenem sensitivity is considered.<\/jats:p>","DOI":"10.1159\/000239332","type":"journal-article","created":{"date-parts":[[2009,9,15]],"date-time":"2009-09-15T08:13:15Z","timestamp":1253002395000},"page":"121-124","source":"Crossref","is-referenced-by-count":3,"title":["Clinical Isolate of a Xanthomonas maltophiliaStrain Producing L-1-Deficient and L-2-lnducible \u03b2-Lactamases"],"prefix":"10.1159","author":[{"given":"Giovanni","family":"Bonfiglio","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefania","family":"Stefani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Nicoletti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,9,11]]},"container-title":["Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/239332","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000239332","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T15:45:13Z","timestamp":1777477513000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000239332"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,9,11]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000239332","archive":["Portico"],"relation":{},"ISSN":["0009-3157","1421-9794"],"issn-type":[{"value":"0009-3157","type":"print"},{"value":"1421-9794","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,9,11]]}}}