{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T13:37:02Z","timestamp":1775655422866,"version":"3.50.1"},"reference-count":21,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2009,9,22]],"date-time":"2009-09-22T00:00:00Z","timestamp":1253577600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,9,22]],"date-time":"2009-09-22T00:00:00Z","timestamp":1253577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; The airway epithelial sodium channel (ENaC) is rate limiting for postnatal alveolar fluid clearance. Increased lung water content is a feature of respiratory distress syndrome (RDS), which is reduced by antenatal corticosteroid treatment in preterm infants. &lt;i&gt;Objectives:&lt;\/i&gt; Since corticosteroids also induce ENaC gene expression, we studied whether a repeat dose of antenatal \u03b2-methasone affects postnatal expression of airway ENaC. &lt;i&gt;Methods:&lt;\/i&gt; 17 pregnant women with imminent preterm birth were randomized to receive a single repeat dose of \u03b2-methasone (12 mg) or placebo (repeat \u03b2-methasone: 8 infants, gestational age (GA) 30.8 \u00b1 2.2 weeks; placebo: 14 infants, GA 30.4 \u00b1 2.7 weeks). Expression of \u03b1-, \u03b2- and \u03b3ENaC subunits in nasal epithelium 1\u20135 and 20\u201329 h postnatally was analyzed with reverse transcription-PCR. &lt;i&gt;Results:&lt;\/i&gt; There were no differences between the study groups in RDS incidence or ENaC subunit expression (all p &gt; 0.38). Regression coefficients for association of \u03b1ENaC expression at 1\u20135 h with GA in infants with and without RDS differed significantly (p = 0.023). At 20\u201329 h, \u03b1ENaC expression was lower in infants with RDS (p = 0.048). &lt;i&gt;Conclusions:&lt;\/i&gt; A single repeat dose of antenatal \u03b2-methasone did not increase ENaC expression, which may in part explain the absence of reduction in RDS incidence.<\/jats:p>","DOI":"10.1159\/000239766","type":"journal-article","created":{"date-parts":[[2009,9,25]],"date-time":"2009-09-25T13:42:34Z","timestamp":1253886154000},"page":"132-138","source":"Crossref","is-referenced-by-count":10,"title":["Expression of Airway Epithelial Sodium Channel in the Preterm Infant Is Related to Respiratory Distress Syndrome but Unaffected by Repeat Antenatal \u03b2-Methasone"],"prefix":"10.1159","volume":"97","author":[{"given":"Cecilia","family":"Jan\u00e9r","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Otto","family":"Helve","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olli M.","family":"Pitk\u00e4nen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Anneli","family":"Kari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Outi M.","family":"Peltoniemi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikko","family":"Hallman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petteri","family":"Hovi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sture","family":"Andersson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,9,22]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-3476%2863%2980218-8"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.resp.2007.10.004"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1038%2Fng0396-325"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038%2F367463a0"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1085%2Fjgp.112.4.423"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-3476%2897%2970198-7"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.113.5.1267"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1074%2Fjbc.274.18.12431"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1203%2F00006450-199908000-00014"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2806%2968846-6"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1001%2Fjama.286.13.1581"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.2006-1549"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1164%2Frccm.200501-052OC"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.2007-0100"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1172%2FJCI108236"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2004-0013"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1203%2F00006450-199006000-00010"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016%2F0002-9378%2895%2990014-4"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00404-001-0271-6"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1038%2Fnm1028"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1165%2Frcmb.2005-0273OC"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/239766","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/239766","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T22:09:33Z","timestamp":1745446173000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000239766"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,9,22]]},"references-count":21,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2010,2,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000239766","archive":["Portico"],"relation":{},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"value":"1661-7800","type":"print"},{"value":"1661-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,9,22]]}}}