{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:45:41Z","timestamp":1745469941008,"version":"3.40.4"},"reference-count":17,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2009,9,17]],"date-time":"2009-09-17T00:00:00Z","timestamp":1253145600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,9,17]],"date-time":"2009-09-17T00:00:00Z","timestamp":1253145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gerontology"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Hyperhomocysteinemia is correlated with diseases and lifestyle habits. However, there is no epidemiological evidence concerning the distribution and prevalence of hyperhomocysteinemia in a local community. &lt;i&gt;Objective: &lt;\/i&gt;The purpose of this study was to clarify the distribution and prevalence of hyperhomocysteinemia and the existence or nonexistence of familial clustering. &lt;i&gt;Methods:&lt;\/i&gt; The subjects were participants in the Basic Health Check Service 1999. We administered a questionnaire and obtained blood samples from 865 subjects (306 men, 559 women) who agreed to participate in our study. &lt;i&gt;Results:&lt;\/i&gt; Hyperhomocysteinemia was present in 52 men (17.0%) and 25 women (4.5%). Ten subjects who had hyperhomosysteinemia ha a family member who also had hyperhomocysteinemia. The odds ratio for hyperhomocysteinemia adjusted for age and sex was 4.77 (p &lt; 0.01, 95% CI = 1.95\u201311.65). &lt;i&gt;Conclusion:&lt;\/i&gt; Hyperhomocysteinemia shows familial clustering. Men and elderly persons were more likely to have hyperhomocysteinemia.<\/jats:p>","DOI":"10.1159\/000240047","type":"journal-article","created":{"date-parts":[[2009,9,16]],"date-time":"2009-09-16T16:23:37Z","timestamp":1253118217000},"page":"15-19","source":"Crossref","is-referenced-by-count":0,"title":["A Cross-Sectional Study of Familial Clustering in Hyperhomocysteinemia"],"prefix":"10.1159","volume":"56","author":[{"given":"Satoko","family":"Mitani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kotaro","family":"Ozasa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masako","family":"Shigeta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nagato","family":"Kuriyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Etsuko","family":"Ozaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiki","family":"Mizuno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Syohei","family":"Yokota","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiyuki","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,9,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3132%2Fdvdr.2007.033"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.cdd.4401451"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1161%2F01.CIR.0000131942.77635.2D"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1751-553X.2007.00907.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.semnephrol.2005.06.002"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1124%2Fpr.54.4.599"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1373%2Fclinchem.2003.021634"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1191%2F1358863x04vm542oa"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1248%2Fjhs.53.16"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007%2Fs11883-007-0048-x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1136%2Fbmj.325.7374.1202"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1136%2Fbmj.39000.486701.68"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1001%2Fjama.296.22.2720"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2362.1992.tb01940.x"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2FS0895-4356%2800%2900341-3"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.83.2.550"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1093%2Fqjmed%2F90.8.519"}],"container-title":["Gerontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/240047","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/240047","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T22:12:51Z","timestamp":1745446371000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000240047"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,9,17]]},"references-count":17,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2010,1,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000240047","archive":["Portico"],"relation":{},"ISSN":["0304-324X","1423-0003"],"issn-type":[{"type":"print","value":"0304-324X"},{"type":"electronic","value":"1423-0003"}],"subject":[],"published":{"date-parts":[[2009,9,17]]}}}