{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T04:37:58Z","timestamp":1762144678910,"version":"3.40.4"},"reference-count":31,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dement Geriatr Cogn Disord"],"published-print":{"date-parts":[[2009]]},"abstract":"<i>Aim:<\/i> We investigated the performance of FDG PET using an automated procedure for discrimination between Alzheimer\u2019s disease (AD) and controls, and studied the influence of demographic and technical factors. <i>Methods:<\/i> FDG PET data were obtained from the Alzheimer\u2019s Disease Neuroimaging Initiative (ADNI) [102 controls (76.0 \u00b1 4.9 years) and 89 AD patients (75.7 \u00b1 7.6 years, MMSE 23.5 \u00b1 2.1) and the Network for Standardisation of Dementia Diagnosis (NEST-DD) [36 controls (62.2 \u00b1 5.0 years) and 237 AD patients (70.8 \u00b1 8.3 years, MMSE 20.9 \u00b1 4.4). The procedure created t-maps of abnormal voxels. The sum of t-values in predefined areas that are typically affected by AD (AD t-sum) provided a measure of scan abnormality associated with a preset threshold for discrimination between patients and controls. <i>Results:<\/i> AD patients had much higher AD t-sum scores compared to controls (p < 0.01), which were significantly related to dementia severity (ADNI: r = \u20130.62, p < 0.01; NEST-DD: r = \u20130.59, p < 0.01). Early-onset AD patients had significantly higher AD t-sum scores than late-onset AD patients (p < 0.01). Differences between databases were mainly due to different age distributions. The predefined AD t-sum threshold yielded a sensitivity and specificity of 83 and 78% in ADNI and 78 and 94% in NEST-DD, respectively. <i>Conclusion:<\/i> The automated FDG PET analysis procedure provided good discrimination power, and was most accurate for early-onset AD.<\/jats:p>","DOI":"10.1159\/000241879","type":"journal-article","created":{"date-parts":[[2009,9,28]],"date-time":"2009-09-28T12:24:24Z","timestamp":1254140664000},"page":"259-266","source":"Crossref","is-referenced-by-count":59,"title":["Performance of FDG PET for Detection of Alzheimer\u2019s Disease in Two Independent Multicentre Samples (NEST-DD and ADNI)"],"prefix":"10.1159","volume":"28","author":[{"given":"C.","family":"Haense","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Herholz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.J.","family":"Jagust","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.D.","family":"Heiss","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,9,25]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2FS1474-4422%2807%2970178-3"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007%2FBF02988444"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1176%2Fappi.ajp.159.5.738"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002%2Fana.410160605"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002%2Fana.410420114"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1001%2Farchneur.62.11.1728"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1001%2Fjama.286.17.2120"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2FS1536-1632%2802%2900016-1"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1006%2Fnimg.2002.1208"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1212%2FWNL.34.7.939"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2F0022-3956%2875%2990026-6"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1002%2Fhbm.460030303"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1259%2Fbjr%2F97295129"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00259-005-0015-0"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1212%2FWNL.45.11.2077"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1093%2Fbrain%2Fawh539"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-510X%2802%2900114-4"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1001%2Farchneur.55.3.326"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1136%2Fjnnp.74.6.715"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1006%2Fnimg.2002.1208"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.2967%2Fjnumed.107.040675"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1212%2F01.wnl.0000228230.26044.a4"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMoa0806142"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.191044198"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.neurobiolaging.2006.12.008"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1093%2Fbrain%2Fawm177"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.2967%2Fjnumed.107.045385"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.neuroimage.2008.01.056"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.neuroimage.2009.01.020"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.neurobiolaging.2007.06.010"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1097%2F01.wad.0000191420.61260.a8"}],"container-title":["Dementia and Geriatric Cognitive Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/241879","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/241879","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T21:31:01Z","timestamp":1745443861000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000241879"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009]]},"references-count":31,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2009,10,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000241879","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.5120839","asserted-by":"subject"}]},"ISSN":["1420-8008","1421-9824"],"issn-type":[{"type":"print","value":"1420-8008"},{"type":"electronic","value":"1421-9824"}],"subject":[],"published":{"date-parts":[[2009]]}}}