{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T21:40:48Z","timestamp":1778276448067,"version":"3.51.4"},"reference-count":16,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Nephrol"],"published-print":{"date-parts":[[2009]]},"abstract":"<i>Background\/Aims:<\/i> Cystic epithelia in polycystic kidney disease display features similar to malignant cells. Thiazolidinediones have been shown to have anti-neoplastic properties, therefore we tested the hypothesis that pioglitazone reduces cyst formation, improves renal function, and prolongs survival in a mouse model of polycystic kidney disease. <i>Methods:<\/i> PC-Pkd1-KO mice, which have homozygous mutations of the <i>Pkd1<\/i> gene in principal cells, were used. On the day after giving birth, mothers were fed standard mouse chow with or without pioglitazone (30 mg\/kg chow). After weaning, the assigned diet was continued. At 1 month of age, blood pressure was measured and animals were sacrificed to determine kidney weight, body weight, and serum urea. Kidneys were evaluated for proliferation using Ki-67, apoptosis using TUNEL analysis, and cyst number using MRI. Survival was observed. <i>Results:<\/i> Pioglitazone did not alter renal function, cell proliferation, apoptosis, or cyst formation in animals with polycystic kidney disease, however it did increase survival. Pioglitazone reduced blood pressure in PC-Pkd1-KO, but not in controls. <i>Conclusion:<\/i> These findings suggest that pioglitazone may have a unique antihypertensive effect in polycystic kidney disease, and that such an effect may promote improved survival.<\/jats:p>","DOI":"10.1159\/000242432","type":"journal-article","created":{"date-parts":[[2009,9,28]],"date-time":"2009-09-28T12:24:24Z","timestamp":1254140664000},"page":"468-473","source":"Crossref","is-referenced-by-count":25,"title":["Effect of Pioglitazone on Survival and Renal Function in a Mouse Model of Polycystic Kidney Disease"],"prefix":"10.1159","volume":"30","author":[{"given":"K.L.","family":"Raphael","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.A.","family":"Strait","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.K.","family":"Stricklett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.C.","family":"Baird","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Piontek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.G.","family":"Germino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.E.","family":"Kohan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,9,24]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.ki.5001620"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1440-1797.2007.00900.x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.ki.5001534"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038%2Fki.2008.659"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1152%2Fajprenal.00398.2005"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1093%2Fndt%2Fgfn157"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.bbrc.2007.07.136"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1152%2Fajprenal.00232.2007"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1093%2Fhmg%2F11.15.1731"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-1755.2003.00185.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1007%2Fs11906-009-0041-6"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1038%2Fnm1278"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.0501744102"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1017%2FS1462399406010362"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.2337%2Fdb05-1683"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.ki.5002570"}],"container-title":["American Journal of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/242432","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/242432","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T21:36:11Z","timestamp":1745444171000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000242432"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009]]},"references-count":16,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2009,11,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000242432","archive":["Portico"],"relation":{},"ISSN":["0250-8095","1421-9670"],"issn-type":[{"value":"0250-8095","type":"print"},{"value":"1421-9670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009]]}}}