{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T20:32:54Z","timestamp":1777926774848,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2009,9,24]],"date-time":"2009-09-24T00:00:00Z","timestamp":1253750400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2009,9,24]],"date-time":"2009-09-24T00:00:00Z","timestamp":1253750400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biol Neonate"],"abstract":"<jats:p>These experiments sought to determine the role of arginine vasopressin (AVP) in the inability of newborns to produce a fever. Our data demonstrate that the AVP analog, [1-\u03b2-mercapto-\u03b2,\u03b2-cyclopentamethylene propionic acid)-2-(O-methyl)tyrosine] arginine vasopressin (M-AVP), administered centrally to adult rats, prevented the antipyretic action of centrally injected AVP. Behaviorally thermoregulating 3-day-old rat pups failed to respond to endoxin with a fever, similar to neonates of other species, but when central AVP antipyretic receptors were blocked by pretreatment with M-AVP, the pups were able to raise their body temperature to febrile levels. The antipyretic drug, indomethacin, prevented these fevers. We conclude that endogenous AVP is a physiologically important antipyretic substance in the brain of the newborn rat.<\/jats:p>","DOI":"10.1159\/000242660","type":"journal-article","created":{"date-parts":[[2009,9,28]],"date-time":"2009-09-28T08:24:24Z","timestamp":1254126264000},"page":"249-254","source":"Crossref","is-referenced-by-count":22,"title":["Vasopressin Functions as an Endogenous Antipyretic in the Newborn"],"prefix":"10.1159","author":[{"given":"Norman W.","family":"Kasting","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marshall F.","family":"Wilkinson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,9,24]]},"container-title":["Biology of the Neonate"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/242660","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000242660","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T22:20:46Z","timestamp":1777674046000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000242660"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,9,24]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000242660","archive":["Portico"],"relation":{},"ISSN":["0006-3126","1421-9727"],"issn-type":[{"value":"0006-3126","type":"print"},{"value":"1421-9727","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,9,24]]}}}