{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T09:41:00Z","timestamp":1791884460829,"version":"4.3.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2009,9,24]],"date-time":"2009-09-24T00:00:00Z","timestamp":1253750400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2009,9,24]],"date-time":"2009-09-24T00:00:00Z","timestamp":1253750400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biol Neonate"],"abstract":"<jats:p>The newborn rabbit was used as an experimental model for studying renal changes during normocapnic hypoxemia. Renal extraction of p-aminohippuric acid (PAH), as assessed in 15 normoxemic and 8 hypoxemic rabbits amounted to 54.6 \u00b1 3.7 and 45.7 \u00b1 4.6%, respectively (NS). Changes in glomerular filtration rate (GFR), and renal blood flow (RBF) as assessed by inulin and PAH clearances, respectively, were determined during norm oxemia and subsequent hypoxemia in 8 additional anesthetized and mechanically ventilated newborn rabbits. Normocapnic hypoxemia (PaO&lt;sub&gt;2&lt;\/sub&gt; = 38.6 \u00b1 2.1 mm Hg) induced a significant fall in GFR from 2.10 \u00b1 0.21 to 1.51 \u00b1 0.18ml\/kg\/min (p &lt; 0.01), in filtration fraction (p &lt; 0.01) and U\/P inulin ratio (p &lt; 0.01). RBF, renal vascular resistance and urine flow rate did not change significantly. In comparison with other immature animal species the newborn rabbit appears a valuable and inexpensive model for the study of acute hypoxemia-induced renal changes.<\/jats:p>","DOI":"10.1159\/000242692","type":"journal-article","created":{"date-parts":[[2009,9,28]],"date-time":"2009-09-28T10:11:01Z","timestamp":1254132661000},"page":"115-120","source":"Crossref","is-referenced-by-count":23,"title":["The Newborn Rabbit: A Model for Studying Hypoxemia-Induced Renal Changes"],"prefix":"10.1159","author":[{"given":"Jean-Bernard","family":"Gouyon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Vallotton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Pierre","family":"Guignard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2009,9,24]]},"container-title":["Biology of the Neonate"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/242692","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000242692","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T22:21:03Z","timestamp":1777674063000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000242692"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,9,24]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000242692","archive":["Portico"],"relation":{},"ISSN":["0006-3126","1421-9727"],"issn-type":[{"value":"0006-3126","type":"print"},{"value":"1421-9727","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,9,24]]}}}