{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:30:07Z","timestamp":1787164207551,"version":"build-2736575974"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2009,9,24]],"date-time":"2009-09-24T00:00:00Z","timestamp":1253750400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2009,9,24]],"date-time":"2009-09-24T00:00:00Z","timestamp":1253750400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biol Neonate"],"abstract":"<jats:p>In order to evaluate the effect of distal endotracheal bias flow during HFOV on PaCO&lt;sub&gt;2&lt;\/sub&gt; we studied adult rabbits with normal lungs and those who had meconium-induced lung dysfunction. Animals were studied while 1.0, 1.4 and 1.8 ml\/kg tidal volumes (V&lt;sub&gt;T&lt;\/sub&gt;) were delivered by a high frequency oscillator. In animals with normal lungs and a 1.0 liter\/min distal bias flow, the PaCO&lt;sub&gt;2&lt;\/sub&gt; decreased significantly (p &lt; 0.01) with all V&lt;sub&gt;T&lt;\/sub&gt; used. In animals with meconium instillation the decrease in PaCO&lt;sub&gt;2&lt;\/sub&gt; was also significant (p &lt; 0.05) at all combinations of V&lt;sub&gt;T&lt;\/sub&gt; and distal bias flow. The higher the distal bias flow the more pronounced was the lowering effect on PaCO&lt;sub&gt;2&lt;\/sub&gt; We conclude that during HFOV it is possible to improve CO&lt;sub&gt;2&lt;\/sub&gt; elimination using small additional bias flow delivered near the tip of the endotracheal tube in animals with normal and abnormal lung function. This may allow adequate alveolar ventilation with even smaller V&lt;sub&gt;T&lt;\/sub&gt;, thus reducing the risk of barotrauma.<\/jats:p>","DOI":"10.1159\/000242764","type":"journal-article","created":{"date-parts":[[2009,9,28]],"date-time":"2009-09-28T10:11:01Z","timestamp":1254132661000},"page":"61-67","source":"Crossref","is-referenced-by-count":4,"title":["Effect of Distal Endotracheal Bias Flow on PaCO\n                    <sub>2<\/sub>\n                    during High Frequency Oscillatory Ventilation"],"prefix":"10.1159","author":[{"given":"Aldo","family":"Bancalari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Bancalari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorothy","family":"Hehre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cleide","family":"Suguihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tilo","family":"Gerhardt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald N.","family":"Goldberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2009,9,24]]},"container-title":["Biology of the Neonate"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/242764","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000242764","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T22:21:38Z","timestamp":1777674098000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000242764"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,9,24]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000242764","archive":["Portico"],"relation":{},"ISSN":["0006-3126","1421-9727"],"issn-type":[{"value":"0006-3126","type":"print"},{"value":"1421-9727","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,9,24]]}}}