{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T14:32:16Z","timestamp":1792247536562,"version":"4.4.0"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2009,9,25]],"date-time":"2009-09-25T00:00:00Z","timestamp":1253836800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2009,9,25]],"date-time":"2009-09-25T00:00:00Z","timestamp":1253836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biol Neonate"],"abstract":"<jats:p>The growth velocity of 46 infants with congenital hypothyroidism, classified into three groups: athyreosis (n = 12), ectopic (n = 25) and eutopic gland (n = 9), was analyzed. Height, expressed as the standard deviation score (SDS), was measured at birth, at diagnosis and 2, 4, and 8 weeks after initiation of therapy. Bone age was retarded at birth and at diagnosis, epiphyseal surfaces of the knee were correlated with serum T&lt;sub&gt;4&lt;\/sub&gt; values. By contrast, height (mean \u00b1 SD) at birth was normal (0.3 \u00b1 0.8 SDS) with identical distribution among the three subgroups. Growth velocity was decreased during the first weeks of life: height at diagnosis was -0.1 \u00b1 0.6 SDS, a value significantly different from size at birth (p &lt; 0.02). After therapy was started, a continuous decline in rowth velocity was observed, reaching-0.2 \u00b1 0.7 and -0.2 \u00b1 0.6 SDS, respectively, at 2 and 4 weeks of therapy (p &lt; 0.01 vs. size at birth). Growth retardation was correlated with the degree of thyroid deficiency. Mean height after 2 weeks of therapy was at -0.6, -0.1 0.1 SDS in patients with athyreosis, ectopic and eutopic gland, respectively. Catch-up growth occurred thereafter, and the mean height reached 0.3 SDS at 12 weeks for the entire group. A correlation between the decrease in growth velocity and T&lt;sub&gt;4&lt;\/sub&gt; levels at diagnosis was found (p &lt; 0.05). The normal size at birth and the decreased growth rate observed at diagnosis seem to indicate that growth becomes thyroid hormone dependent immediately after birth.<\/jats:p>","DOI":"10.1159\/000242920","type":"journal-article","created":{"date-parts":[[2009,9,28]],"date-time":"2009-09-28T08:24:24Z","timestamp":1254126264000},"page":"218-223","source":"Crossref","is-referenced-by-count":26,"title":["Congenital Hypothyroidism: Decreased Growth Velocity in the First Weeks of Life"],"prefix":"10.1159","author":[{"given":"J.","family":"Leger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Czernichow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2009,9,25]]},"container-title":["Biology of the Neonate"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/242920","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000242920","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T22:23:04Z","timestamp":1777674184000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000242920"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,9,25]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000242920","archive":["Portico"],"relation":{},"ISSN":["0006-3126","1421-9727"],"issn-type":[{"value":"0006-3126","type":"print"},{"value":"1421-9727","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,9,25]]}}}