{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T03:33:36Z","timestamp":1758944016515,"version":"3.40.4"},"reference-count":29,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Haematol"],"published-print":{"date-parts":[[2009]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Myeloproliferative neoplasms likely involve both myeloid and lymphoid lineages. Nevertheless, the coincidence of chronic myeloproliferative and lymphoproliferative diseases in the same patient is a rare phenomenon. &lt;i&gt;Methods:&lt;\/i&gt; We report a case of a patient having essential thrombocythemia (ET) and B-chronic lymphocytic leukemia (B-CLL). In this patient and in 2 relatives with lymphoproliferative disorders, we searched for JAK2&lt;sup&gt;V617F&lt;\/sup&gt; mutation in lymphocytes. &lt;i&gt;Results:&lt;\/i&gt; In the patient with ET and B-CLL, we identified homozygous JAK2&lt;sup&gt;V617F&lt;\/sup&gt; mutation in the granulocytic compartment. Both relatives were heterozygous for JAK2&lt;sup&gt;V617F&lt;\/sup&gt; mutation, whereas no mutation signal could be detected in the lymphoid compartment of all 3 patients. &lt;i&gt;Conclusion:&lt;\/i&gt; Our results seem to confirm that CLL cases are negative for JAK2&lt;sup&gt;V617F&lt;\/sup&gt; mutation in B- and T-lymphocyte populations.Presence of JAK2&lt;sup&gt;V617F&lt;\/sup&gt; mutation in subjects without myeloproliferative diseases could indicate an increased risk of a future myeloproliferative neoplasm development.<\/jats:p>","DOI":"10.1159\/000243721","type":"journal-article","created":{"date-parts":[[2009,10,7]],"date-time":"2009-10-07T11:08:20Z","timestamp":1254913700000},"page":"46-49","source":"Crossref","is-referenced-by-count":9,"title":["Absence of the V617F JAK2 Mutation in the Lymphoid Compartment in a Patient with Essential Thrombo- cythemia and B-Chronic Lymphocytic Leukemia and in Two Relatives with Lymphoproliferative Disorders"],"prefix":"10.1159","volume":"122","author":[{"given":"Caterina","family":"Musolino","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Allegra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppa","family":"Penna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raffaella","family":"Centorrino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Cuzzola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arianna","family":"D\u2019Angelo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pasquale","family":"Iacopino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Alonci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,10,7]]},"reference":[{"doi-asserted-by":"publisher","key":"ref1","DOI":"10.1016%2Fj.blre.2004.02.002"},{"doi-asserted-by":"publisher","key":"ref2","DOI":"10.1172%2FJCI111840"},{"doi-asserted-by":"publisher","key":"ref3","DOI":"10.1007%2Fs00292-002-0578-5"},{"doi-asserted-by":"publisher","key":"ref4","DOI":"10.1046%2Fj.1365-2257.1998.00170.x"},{"doi-asserted-by":"publisher","key":"ref5","DOI":"10.1136%2Fjcp.43.5.357"},{"doi-asserted-by":"publisher","key":"ref6","DOI":"10.1038%2Fmodpathol.3800225"},{"doi-asserted-by":"publisher","key":"ref7","DOI":"10.1038%2Fmodpathol.3800225"},{"doi-asserted-by":"publisher","key":"ref8","DOI":"10.1111%2Fj.1365-2141.2005.05682.x"},{"doi-asserted-by":"publisher","key":"ref9","DOI":"10.1111%2Fj.0902-4441.2006.t01-1-EJH2940.x"},{"doi-asserted-by":"publisher","key":"ref10","DOI":"10.1182%2Fblood-2006-04-017392"},{"doi-asserted-by":"publisher","key":"ref11","DOI":"10.1016%2Fj.leukres.2008.09.002"},{"doi-asserted-by":"publisher","key":"ref12","DOI":"10.1182%2Fblood-2005-05-1898"},{"doi-asserted-by":"publisher","key":"ref13","DOI":"10.1182%2Fblood-2003-10-3545"},{"doi-asserted-by":"publisher","key":"ref14","DOI":"10.1182%2Fblood-2004-09-3701"},{"doi-asserted-by":"publisher","key":"ref15","DOI":"10.1016%2FS0959-437X%2800%2900227-6"},{"doi-asserted-by":"publisher","key":"ref16","DOI":"10.1182%2Fblood-2004-07-2839"},{"doi-asserted-by":"publisher","key":"ref17","DOI":"10.1016%2Fj.cancergencyto.2006.12.007"},{"doi-asserted-by":"publisher","key":"ref18","DOI":"10.1002%2Fajh.20870"},{"doi-asserted-by":"publisher","key":"ref19","DOI":"10.1038%2Fmodpathol.2008.207"},{"doi-asserted-by":"publisher","key":"ref20","DOI":"10.1634%2Fstemcells.2007-0175"},{"doi-asserted-by":"publisher","key":"ref21","DOI":"10.1038%2Fsj.leu.2404749"},{"doi-asserted-by":"publisher","key":"ref22","DOI":"10.1016%2Fj.exphem.2007.08.025"},{"doi-asserted-by":"publisher","key":"ref23","DOI":"10.1111%2Fj.1538-7836.2007.02384.x"},{"doi-asserted-by":"publisher","key":"ref24","DOI":"10.1007%2Fs00277-007-0351-1"},{"doi-asserted-by":"publisher","key":"ref25","DOI":"10.1038%2Fsj.leu.2404292"},{"doi-asserted-by":"publisher","key":"ref26","DOI":"10.1159%2F000111532"},{"doi-asserted-by":"publisher","key":"ref27","DOI":"10.1056%2FNEJMoa051113"},{"doi-asserted-by":"publisher","key":"ref28","DOI":"10.1093%2Fjnci%2F86.21.1600"},{"doi-asserted-by":"publisher","key":"ref29","DOI":"10.1532%2FIJH97.E0304"}],"container-title":["Acta 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