{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T21:43:38Z","timestamp":1780695818247,"version":"3.54.1"},"reference-count":19,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Haematol"],"published-print":{"date-parts":[[2009]]},"abstract":"<jats:p>A 66-year-old Japanese woman was referred to us because of severe anemia and fever and presented at our hospital. She was eventually diagnosed as having acute myeloblastic leukemia (AML; M0) with non-Hodgkin lymphoma (NHL). We investigated the therapeutic efficacy of &lt;i&gt;L&lt;\/i&gt;-asparaginase (&lt;i&gt;L&lt;\/i&gt;-Asp), vincristine and prednisolone for both her AML and NHL. Asparagine synthetase (AS) activity in her AML blast cells was undetectable. A lymph node biopsy specimen revealed NHL of the marginal zone B cell type. Complete remission (CR) of AML and NHL was achieved. CR of the AML lasted for 18 months without further consolidation therapy. We conclude that &lt;i&gt;L&lt;\/i&gt;-Asp can be an effective drug for the treatment of AML in which blasts are negative for AS.<\/jats:p>","DOI":"10.1159\/000243725","type":"journal-article","created":{"date-parts":[[2009,10,7]],"date-time":"2009-10-07T11:08:20Z","timestamp":1254913700000},"page":"54-57","source":"Crossref","is-referenced-by-count":5,"title":["Effect of &lt;i&gt;L&lt;\/i&gt;-Asparaginase Combined with Vincristine and Prednisolone on Acute Myeloblastic Leukemia (M0) Associated with Non-Hodgkin Lymphoma"],"prefix":"10.1159","volume":"122","author":[{"given":"Akira","family":"Horikoshi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiro","family":"Takei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriyoshi","family":"Iriyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kumi","family":"Uenogawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hikaru","family":"Ishizuka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidetaka","family":"Shiraiwa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshifumi","family":"Hosokawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigemasa","family":"Sawada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiyuki","family":"Kitoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2009,10,7]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2F0002-9343%2875%2990600-2"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2875%2992007-3"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002%2F1097-0142%2819820815%2950%3A4%3C676%3A%3AAID-CNCR2820500410%3E3.0.CO%3B2-B"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002%2F1097-0142%28197909%2944%3A3%3C1070%3A%3AAID-CNCR2820440341%3E3.0.CO%3B2-1"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002%2F1097-0142%2819810401%2947%3A7%3C1849%3A%3AAID-CNCR2820470722%3E3.0.CO%3B2-X"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2F0753-3322%2890%2990110-U"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002%2F1097-0142%28197912%2944%3A6%3C2316%3A%3AAID-CNCR2820440647%3E3.0.CO%3B2-6"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.3109%2F10428199209067617"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291096-8652%28199808%2958%3A4%3C278%3A%3AAID-AJH5%3E3.0.CO%3B2-N"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2141.2001.03139.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2FS0165-4608%2801%2900579-9"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.leu.2402174"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007%2FBF02986617"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.yexmp.2005.02.003"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1159%2F000225175"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1097%2F00002030-200205240-00009"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016%2F0006-2952%2869%2990375-X"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1097%2F00001813-200503000-00006"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1002%2F1097-0142%28197002%2925%3A2%3C279%3A%3AAID-CNCR2820250205%3E3.0.CO%3B2-7"}],"container-title":["Acta Haematologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/243725","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/243725","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T21:49:13Z","timestamp":1745444953000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000243725"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009]]},"references-count":19,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2009,10,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000243725","archive":["Portico"],"relation":{},"ISSN":["0001-5792","1421-9662"],"issn-type":[{"value":"0001-5792","type":"print"},{"value":"1421-9662","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009]]}}}