{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:01:04Z","timestamp":1790744464096,"version":"4.1.0"},"reference-count":24,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2009,12,22]],"date-time":"2009-12-22T00:00:00Z","timestamp":1261440000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,12,22]],"date-time":"2009-12-22T00:00:00Z","timestamp":1261440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digestion"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Functional dyspepsia (FD) is a common disorder, but information on its natural history is limited. &lt;i&gt;Aim:&lt;\/i&gt; To study the natural history of FD as assessed by 2 criteria over a 10-year period. &lt;i&gt;Method:&lt;\/i&gt; A population-based study conducted by mailing a questionnaire to the same age- and gender-stratified random sample of the Icelandic population aged 18\u201375 in 1996 and again in 2006. FD was estimated by the Functional Dyspepsia Score List and by dyspepsia subgroups categorized into 4 groups: (1) frequent upper pain, (2) meal-related, (3) nausea or vomiting, and (4) combinations of these groups. &lt;i&gt;Results:&lt;\/i&gt; FD was diagnosed in 13.9% of the subjects in the 1996 sample (11.3% male, 15.8% female) and 16.7% in 2006 (12.3% male, 20.2% female) with a significant difference between males and females in 2006. Dyspepsia subgroup criteria showed a higher prevalence than conventional FD criteria. The proportion of FD subjects in one of the dyspepsia subgroups was low. There was a significant relationship between FD and heartburn and irritable bowel syndrome. A high proportion of subjects who seek medical care have FD. &lt;i&gt;Conclusion:&lt;\/i&gt; FD was stable over the 10-year period, but there was turnover in symptoms and increased intensity and frequency of gastrointestinal pain. Dyspepsia subgroup criteria showed a higher prevalence than FD, which was more common in young subjects and females. FD poses a heavy burden on the health care system.<\/jats:p>","DOI":"10.1159\/000243783","type":"journal-article","created":{"date-parts":[[2009,12,23]],"date-time":"2009-12-23T08:12:31Z","timestamp":1261555951000},"page":"53-61","source":"Crossref","is-referenced-by-count":53,"title":["Natural History of Functional Dyspepsia: A 10-Year Population-Based Study"],"prefix":"10.1159","volume":"81","author":[{"given":"Linda Bjork","family":"Olafsdottir","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hallgr\u00edmur","family":"Gudjonsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidur Hrund","family":"Jonsdottir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bjarni","family":"Thjodleifsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2009,12,22]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2982.2004.00581.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1053%2Fj.gastro.2007.06.010"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2F0016-5085%2895%2990373-9"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1053%2Fgast.2003.50155"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1053%2Fj.gastro.2003.06.008"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1053%2Fgast.2001.28656"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1572-0241.2007.01381.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1136%2Fgut.45.2008.ii37"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1572-0241.2007.01080.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1136%2Fgut.31.4.401"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1053%2Fj.gastro.2005.11.059"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1080%2F003655299750025192"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007%2FBF00845390"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1136%2Fbmj.2.6138.653"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1572-0241.1999.01281.x"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1053%2Fj.gastro.2005.10.019"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2982.2006.00815.x"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1023%2FA%3A1018878717715"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1572-0241.2002.05783.x"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016%2FS1542-3565%2805%2900153-9"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1080%2F003655202760230874"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1080%2F003655299750025237"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1159%2F000050679"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1001%2Fjama.295.13.1566"}],"container-title":["Digestion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/243783","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/243783","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T21:49:40Z","timestamp":1745444980000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000243783"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,12,22]]},"references-count":24,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2010,2,1]]},"published-print":{"date-parts":[[2010,2,25]]}},"URL":"https:\/\/doi.org\/10.1159\/000243783","archive":["Portico"],"relation":{},"ISSN":["0012-2823","1421-9867"],"issn-type":[{"value":"0012-2823","type":"print"},{"value":"1421-9867","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,12,22]]}}}