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Using a logistic regression model, the effects of therapy, birthweight, sex, hospital and other clinical factors on survival and various outcome parameters were evaluated. Mortality (13 vs. 21 %, p &lt; 0.05) and the incidence of pneumothorax (9 vs. 18%, p &lt; 0.01) were significantly lower in the multiple-dose group. Low birthweight, hospital allocation, low Apgar score and initial disease severity were associated with an increased mortality. Low birthweight, hypothermia (admission temperature &lt; 36\u00b0C) and acidosis (pH &lt; 7.25) prior to surfactant treatment could be identified as risk factors for the development of intracranial hemorrhage.<\/jats:p>","DOI":"10.1159\/000243840","type":"journal-article","created":{"date-parts":[[2009,10,2]],"date-time":"2009-10-02T06:01:57Z","timestamp":1254463317000},"page":"26-30","source":"Crossref","is-referenced-by-count":26,"title":["Factors Influencing Morbidity and Mortality in Infants with Severe Respiratory Distress Syndrome Treated with Single or Multiple Doses of a Natural Porcine 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