{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T20:35:30Z","timestamp":1777926930110,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2009,9,30]],"date-time":"2009-09-30T00:00:00Z","timestamp":1254268800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2009,9,30]],"date-time":"2009-09-30T00:00:00Z","timestamp":1254268800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biol Neonate"],"abstract":"<jats:p>Birth asphyxia is an important cause of permanent neuro-developmental disability. Asphyxia sets in course a progression of intracellular events which culminates in neuronal death, and this process may take up to 48 h to complete. Entry of calcium into the neurone appears to be the key to the cell death, and it is known that during asphyxia, excessive glutamate is released which stimulates the voltage-dependent N-methyl-D-aspartate (NMDA) receptor to open with an accumulation of excess intracellular calcium. MK-801 is a very effective NMDA receptor antagonist, and it has been shown that this drug prevents or significantly reduces the extent of cortical neurone infarction following experimental asphyxia in 7-day-old rat pups. Unfortunately, MK-801 is toxic to the pup, but newer NMDA receptor antagonists may offer the opportunity for neuroprotection in the human infant who has suffered severe birth asphyxia.<\/jats:p>","DOI":"10.1159\/000243878","type":"journal-article","created":{"date-parts":[[2009,10,2]],"date-time":"2009-10-02T05:47:33Z","timestamp":1254462453000},"page":"248-251","source":"Crossref","is-referenced-by-count":18,"title":["Role of Excitatory Amino Acid Antagonists in the Management of Birth Asphyxia"],"prefix":"10.1159","author":[{"given":"Malcolm","family":"Levene","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,9,30]]},"container-title":["Biology of the Neonate"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/243878","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000243878","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T22:27:19Z","timestamp":1777674439000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000243878"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,9,30]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000243878","archive":["Portico"],"relation":{},"ISSN":["0006-3126","1421-9727"],"issn-type":[{"value":"0006-3126","type":"print"},{"value":"1421-9727","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,9,30]]}}}