{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T12:59:46Z","timestamp":1791118786242,"version":"4.1.0"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2009,9,30]],"date-time":"2009-09-30T00:00:00Z","timestamp":1254268800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2009,9,30]],"date-time":"2009-09-30T00:00:00Z","timestamp":1254268800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biol Neonate"],"abstract":"<jats:p>We proposed that hypoxic-ischemic injury suffered on postnatal day 1 (P1) in the newborn rat would yield significant and reproducible brain injury simulating that seen in a midgestation human brain. The P1 pup was subjected to ipsilateral common carotid ligation followed by 3.5 h of 6% O&lt;sub&gt;2&lt;\/sub&gt; and demonstrated consistent histological changes in the ipsilateral hemisphere. At P2 neuronal loss and edema were pronounced in cortex and caudate; edema subsequently declined by P3. Astrocytic and microglial reactivity were seen as early as 24 h after injury, and by P10 both were extensive in damaged areas. There was marked loss of white matter on the affected side. We have demonstrated a reproducible model of hypoxic-ischemic injury to the very immature brain that can be used to elucidate mechanisms of neuronal loss and periventricular leukomalacia.<\/jats:p>","DOI":"10.1159\/000244327","type":"journal-article","created":{"date-parts":[[2009,10,2]],"date-time":"2009-10-02T06:01:57Z","timestamp":1254463317000},"page":"327-341","source":"Crossref","is-referenced-by-count":92,"title":["A Rat Model for Hypoxic-Ischemic Brain Damage in Very Premature Infants"],"prefix":"10.1159","author":[{"given":"Ann","family":"Sheldon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Chuai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donna M.","family":"Ferriero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2009,9,30]]},"container-title":["Biology of the Neonate"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/244327","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000244327","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T22:32:07Z","timestamp":1777674727000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000244327"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,9,30]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000244327","archive":["Portico"],"relation":{},"ISSN":["0006-3126","1421-9727"],"issn-type":[{"value":"0006-3126","type":"print"},{"value":"1421-9727","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,9,30]]}}}